Effect of antiprotozoal molecules on hypnospores of Perkinsus spp. parasite

Experimental Parasitology
Sâmia Sousa DuartePatricia Mirella da Silva

Abstract

Perkinsus protozoan parasites have been associated with high mortality of bivalves worldwide, including Brazil. The use of antiproliferative drugs to treat the Perkinsosis is an unusual prophylactic strategy. However, because of their environment impact it could be used to control parasite proliferation in closed system, such as hatchery. This study evaluated the anti-Perkinsus activity potential of synthesized and commercial compounds. Viability of hypnospores of Perkinsus spp. was assessed in vitro. Cells were incubated with three 2-amino-thiophene (6AMD, 6CN, 5CN) and one acylhydrazone derivatives (AMZ-DCL), at the concentrations of 31.25; 62.5; 125; 250 and 500 μM and one commercial chlorinated phenoxy phenol derivative, triclosan (2, 5, 10 and 20 μM), for 24-48 h. Two synthetic molecules (6CN and AMZ-DCL) caused a significant decline (38 and 39%, respectively) in hypnospores viability, at the highest concentration (500 μM), after 48 h. Triclosan was the most cytotoxic compound, causing 100% of mortality at 20 μM after 24 h and at 10 μM after 48 h. Cytotoxic effects of the compounds 6CN, AMZ-DCL, and triclosan were investigated by measuring parasite's zoosporulation, morphological changes and metabolic activities (esterase ...Continue Reading

References

Feb 13, 2001·Molecular and Biochemical Parasitology·P Gerold, R T Schwarz
May 23, 2001·Archives of Biochemistry and Biophysics·J VillalaínV Micol
May 30, 2002·Molecular and Biochemical Parasitology·Eric D Lund, Fu-Lin E Chu
Aug 16, 2003·Biomolecular Engineering·Laurence M ElandalloussiM Leonor Cancela
Jan 10, 2004·European Biophysics Journal : EBJ·Jaime GuillénJosé Villalaín
Oct 27, 2004·Bioorganic & Medicinal Chemistry Letters·Isabel C F R FerreiraMaria-João R P Queiroz
Sep 16, 2005·Journal of Medicinal Chemistry·Simon M JonesIan H Gilbert
Nov 3, 2005·Bioorganic & Medicinal Chemistry Letters·Patricia MelnykPhilippe Grellier
Apr 25, 2008·European Journal of Medicinal Chemistry·Issa M I FakhrSiham M el-Shenawy
Feb 27, 2010·Diseases of Aquatic Organisms·Rachel Costa SabryPatricia Mirella da Silva
Jul 8, 2010·European Journal of Medicinal Chemistry·Samir BondockMohamed A Metwally
Sep 23, 2010·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Jia-Long FangPaul Howard
Apr 28, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Helena Teru TakahashiCelso Vataru Nakamura
Jun 28, 2011·Research in Microbiology·Aurélie LelongPhilippe Soudant
Nov 30, 2011·Antioxidants & Redox Signaling·Chinmay Pal, Uday Bandyopadhyay
Mar 1, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luciana ScottiFrancisco Jaime Bezerra Mendonça Junior
Apr 3, 2012·Journal of Invertebrate Pathology·Jorge Cáceres-MartínezRyan B Carnegie
Apr 24, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wen GuZhuhui Chen
Jul 4, 2012·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Beatriz C C SouzaFrancisco J B Mendonça
Sep 25, 2012·European Journal of Protistology·Sandra M Casas, Jerome F La Peyre
Nov 14, 2012·Journal of Invertebrate Pathology·Rachel Costa SabryPatrícia Mirella da Silva
Jan 29, 2013·European Journal of Medicinal Chemistry·Julio BenítezDinorah Gambino
Jul 6, 2013·Progress in Lipid Research·Srinivasan RamakrishnanPeter Bütikofer
Jul 23, 2013·Journal of Invertebrate Pathology·Philippe SoudantAswani Volety
Jul 12, 2014·Chemical Research in Toxicology·Darja GramecMarija Sollner Dolenc
Dec 10, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Samir Aquino CarvalhoCarlos Alberto Manssour Fraga
Jan 3, 2015·Parasitology·Fernando Ramos QueirogaPatricia Mirella Da Silva
Feb 11, 2015·Diseases of Aquatic Organisms·Cécile DangKimberly S Reece
Jun 4, 2015·Journal of Invertebrate Pathology·Lionel DégremontStandish K Allen
Jul 7, 2015·Journal of Invertebrate Pathology·C J RodgersP M Hine
Oct 30, 2015·European Journal of Medicinal Chemistry·Klinger Antonio da Franca RodriguesMárcia Rosa de Oliveira

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved