Effect of Antiretroviral Therapy on Bone and Renal Health in Young Adults Infected With HIV in Early Life

The Journal of Clinical Endocrinology and Metabolism
Aylin B UnsalColleen M Hadigan

Abstract

HIV antiretroviral (ARV) therapy is associated with renal and bone toxicity, but little is known about the potential cumulative effects in adults exposed to ARVs from birth. To prospectively evaluate renal and bone health in young adults with lifelong HIV and extensive ARV exposure. Cross-sectional comparison of bone mineral density (BMD) by dual-energy X-ray absorptiometry, bone turnover, and renal function in young adults infected with HIV in early life (n = 65) to matched healthy controls (n = 23) and longitudinal evaluation (mean follow-up = 4.4 years) within a subset of the HIV cohort (n = 33). Government outpatient research clinic. Albumin/creatinine ratio, protein/creatinine ratio, anion gap, N-terminal telopeptides, and osteocalcin were significantly increased in persons with HIV compared with controls, whereas whole-body BMD and BMD z scores were lower. Within the HIV group, duration of tenofovir disoproxil fumarate (TDF) correlated with higher anion gap but did not correlate with bone parameters. Longer duration of didanosine and stavudine use correlated with lower BMD and BMD z scores. Longitudinal analyses revealed that BMD and bone metabolism significantly improved over time. No subject had an estimated glomerular ...Continue Reading

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Sep 9, 2017·Infectious Diseases·Ankur Kumar JindalRakesh Kumar Pilania
Sep 17, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Lisa FrigatiHeather Zar
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