Effect of Antiretroviral Therapy on Plasma Concentrations of Chloroquine and Desethyl-chloroquine.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Matthew M IppolitoCharles Flexner

Abstract

The effect of antiretroviral therapy (ART) on chloroquine and desethyl-chloroquine plasma concentrations was evaluated in clinical trial participants. Concentrations did not differ among participants receiving protease inhibitor-based ART (n = 9), efavirenz-based ART (n = 15), or other ART (n = 8) and those not receiving ART (n = 31). Efavirenz seemed to inhibit chloroquine desethylation.

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Citations

Jun 1, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Matthew M Ippolito, Charles Flexner
Apr 14, 2019·Current Infectious Disease Reports·Daniel L BourquePaul E Sax

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