Effect of antiretroviral therapy use and adherence on the risk of hyperlipidemia among HIV-infected patients, in the highly active antiretroviral therapy era

Oncotarget
Fuu-Jen TsaiYing-Ju Lin

Abstract

HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan. Hyperlipidemia risk associated with cumulative ART use, ART adherence, and their combination was assessed. The matched hyperlipidemia group had a larger number of patients using ART and a higher incidence of comorbidities, specifically, respiratory disease and diabetes. Patients with high ART dosage and dose-dependent manner adherence, respectively, demonstrated an increased risk of hyperlipidemia. For single ART regimens, patients receiving nucleoside reverse-transcriptase inhibitors (NRTI/NRTI)- containing regimen had the highest hyperlipidemia risk, followed by protease inhibitor (PI)- containing and non-NRTI- containing regimens. For combina...Continue Reading

References

Jan 1, 1995·The American Journal of Medicine·A Tal, L Dall
Aug 1, 1993·The American Journal of Medicine·A Tal, L Dall
May 29, 2000·Scandinavian Journal of Infectious Diseases·S R Penzak, S K Chuck
Feb 4, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adriana AmmassariUNKNOWN AdICoNA Study Group. LipoICoNA Study Group
Nov 15, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Megan E O'BrienPatricia Kissinger
Jan 6, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Renslow Sherer
Nov 15, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Simon P JonesGraeme J Moyle
Sep 27, 2006·Antimicrobial Agents and Chemotherapy·Matthieu ProtBernard Binétruy
Oct 27, 2006·HIV Clinical Trials·M FloridiaUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
Mar 17, 2007·International Journal of STD & AIDS·Martin LecheltAnnemiek de Ruiter
Apr 27, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Kathryn AnastosJessica Justman
Nov 11, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·D J JevtovićO Djurković-Djaković
May 16, 2009·AIDS·Adeel A ButtUNKNOWN Veterans Aging Cohort Study
Oct 26, 2010·Antiviral Research·Paul J PistellAnnadora J Bruce-Keller
Jan 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Chandrasekaran PadmapriyadarsiniSoumya Swaminathan
Jul 20, 2011·The New England Journal of Medicine·Myron S CohenUNKNOWN HPTN 052 Study Team
Nov 18, 2011·The American Journal of Clinical Nutrition·Daniel J Raiten
Mar 14, 2012·British Journal of Hospital Medicine·Mohammed LamordeConcepta Merry
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Julieta Díaz-DelfínFrancesc Villarroya
May 4, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Baiba K GillardHenry J Pownall
Aug 22, 2013·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Asa M MargolisAndrew Stolbach
Sep 7, 2013·Journal of the International AIDS Society·Iris UsachJosé-Esteban Peris
Sep 21, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·I Tong MakWilliam B Weglicki
Dec 10, 2013·BioMed Research International·Elaine Regina Delicato de AlmeidaMaria Angelica Ehara Watanabe
Aug 28, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Khaled Z Abd-ElmoniemAhmed M Gharib
Nov 14, 2014·Journal of the International AIDS Society·Shu-Hsing ChengNa-Lee Sun
Feb 7, 2015·PloS One·Graeme J MoyleUNKNOWN ROCKET 1 (Randomized Open Label Switch for Cholesterol Elevation on Kivexa Evaluation Trial) Study Group
Apr 22, 2015·HIV/AIDS : Research and Palliative Care·Zhengtong LvYong Wang
Aug 25, 2015·International Journal of Cancer. Journal International Du Cancer·Mei-Jyh ChenPau-Chung Chen
Aug 25, 2015·International Journal of Chronic Obstructive Pulmonary Disease·Hee Jin ParkKyung Soo Chung

❮ Previous
Next ❯

Citations

Mar 31, 2018·Current Opinion in Cardiology·Anjly JainDevaki R Nair
Sep 21, 2018·Frontiers in Pharmacology·Fuu-Jen TsaiYing-Ju Lin
Jul 22, 2021·International Journal of Antimicrobial Agents·Yu-Lin LeeUNKNOWN Taiwan HIV Study Group

❮ Previous
Next ❯

Software Mentioned

Statistical Analysis System ( SAS )

Related Concepts

Related Feeds

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Jean-Jacques ParientiESPOIR and REACH study groups
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Yu-Tzu TsengShan-Chwen Chang
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Peter G CardielloD Cooper
© 2022 Meta ULC. All rights reserved