PMID: 6973376Apr 1, 1981Paper

Effect of antithymocyte globulin on bone marrow colony-forming capacity during defective myelopoiesis

Biulleten' eksperimental'noĭ biologii i meditsiny
N A TorubarovaM A Soldatova

Abstract

The effect of antithymocytic globulin (ATG) on colony-forming and claster-forming capacity (CFC and ClFC) of the bone marrow in vitro was studied in patients with hypoplastic anemia. 15 children in the initial stage of the disease and 6 patients before and after splenectomy were examined. The initial CFC and ClFC of the bone marrow were 1.84 +/- 0.55 and 1.92 +/- 0.32, respectively, per 10(5) myelokaryocytes. After the treatment of the bone marrow cell suspension with ATG the characteristics of CFC and ClFC remained unchanged: CFC amounted to 1.72 +/- 0.5 and ClFC to 1.81 +/- 0.27 per 10(5) cells (P greater than 0.05). It has been discovered after splenectomy that ATG produced no effect whatsoever on the colony-forming capacity of bone marrow granulocytic precursors.

References

Oct 1, 1978·Transplantation·C D BucknerE D Thomas
Mar 27, 1976·Lancet·J AscensãoR Good
Jul 1, 1979·British Journal of Haematology·A FailleY Najean
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·W A KaganR A Good
Jan 1, 1978·Annales de génétique et de sélection animale·J Lauvergne

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Citations

Jul 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V I Chumakov
Oct 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu A Kozlov, T A Loktiushina
Jul 1, 1995·Biulleten' eksperimental'noĭ biologii i meditsiny·Iu A KozlovA N Baĭkov
Oct 17, 2008·Bulletin of Experimental Biology and Medicine·G N Zyuz'kovE D Gol'dberg

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