Effect of AP1 transcription factors on the regulation of transcription in normal human epidermal keratinocytes

The Journal of Investigative Dermatology
A RossiN G Markova

Abstract

The conversion of basal keratinocytes to spinous and granular cells is accompanied by the synthesis of a series of epidermal proteins in a differentiation-specific pattern. The transcription of several of these epidermal marker genes is regulated by activator protein 1 (AP1) interactions at their promoter regions. In the epidermis the various AP1 transcription factors are not present uniformly but appear to have a differentiation-specific distribution. We have explored whether the AP1 regulated expression of the keratin 5, transglutaminase 1, involucrin, and loricrin genes reflects the distribution of the AP1 factors in the epidermis. We have found that c-jun and junD activate and junB downregulates the transcription of both basal and suprabasal genes. The effect of c-jun is exerted through interactions with c-fos at the AP1 motifs in the target promoters, whereas both junB and junD act independently of the binding at the AP1 sites. Thus c-jun and junD act as general positive regulators whereas junB acts as a general suppressor of epidermal-specific genes. Therefore, the differentiation specificity of the AP1 regulation must be determined not only by the formation of distinct DNA/AP1 complexes but also by interactions involving...Continue Reading

References

Aug 1, 1992·The Journal of Investigative Dermatology·M OhtsukiM Blumenberg
Jan 11, 1992·Nucleic Acids Research·S Faisst, S Meyer
Dec 10, 1991·Biochimica Et Biophysica Acta·P Angel, M Karin
Oct 1, 1991·The Journal of Investigative Dermatology·N Basset-SéguinJ J Guilhou
Apr 1, 1990·The Journal of Investigative Dermatology·N Basset-SéguinJ J Guilhou
Dec 1, 1990·The Journal of Cell Biology·E Fuchs
Dec 1, 1989·Current Opinion in Cell Biology·F M Watt
Oct 1, 1994·Current Opinion in Genetics & Development·E Fuchs, C Byrne
Sep 8, 1995·The Journal of Biological Chemistry·J M NavarroJ L Jorcano
Feb 24, 1995·Cell·D Thanos, T Maniatis
Jan 5, 1996·The Journal of Biological Chemistry·E Lopez-BayghenL M Alvarez-Salas
Jan 1, 1996·Molecular Biology Reports·R L Eckert, J F Welter

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Citations

Jan 5, 2011·The Journal of Biological Chemistry·Rebecca Walsh, Miroslav Blumenberg
Mar 14, 2000·Molecular and Cellular Biology·S SinhaE Fuchs
Sep 21, 2007·The Journal of Investigative Dermatology·James F Crish, Richard L Eckert
Jun 19, 2009·The Journal of Investigative Dermatology·Ikuko NumataSetsuya Aiba
Jan 19, 2005·The Journal of Investigative Dermatology·Denis MehicErwin Tschachler
Jun 12, 2004·The Journal of Investigative Dermatology·Matthias SchmuthKenneth R Feingold
Sep 5, 2009·European Journal of Immunology·Javier García-CecaAgustín G Zapata
Jun 10, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S-K LeeE-C Kim
Apr 26, 2006·The British Journal of Dermatology·C SadahiraY Kubota
Feb 14, 2002·The Journal of Investigative Dermatology·Isabella SaviniLuciana Avigliano
Jan 5, 2000·The Journal of Investigative Dermatology·I R HarrisK P Wittern
Apr 17, 2004·The Journal of Investigative Dermatology·Samantha GangnussTimothy E Rayner
Jul 24, 2004·Differentiation; Research in Biological Diversity·Claudia PopaNicholas A Saunders
Feb 27, 2010·Biochemical and Biophysical Research Communications·Nagisa KamiokaMotoi Ohba
Jun 7, 2003·Developmental Cell·Guochun LiRandall S Johnson
Sep 24, 2013·The Journal of Allergy and Clinical Immunology·Atsushi OtsukaKenji Kabashima
Apr 3, 1999·The Journal of Biological Chemistry·P A XuR E Kellems
Oct 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S Nishikawa
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·J Rinehart-KimT Bos
Oct 31, 2000·Microscopy Research and Technique·D AberdamP Simon-Assmann
Dec 5, 1998·The Journal of Biological Chemistry·A S TakaokaS Hirohashi
Oct 30, 2004·Journal of Leukocyte Biology·Katherine A GaussMark T Quinn
Apr 14, 2005·Nutrition Reviews·Maria Valeria CataniLuciana Avigliano

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