PMID: 11900963Mar 20, 2002Paper

Effect of apoptosis on phagocytosis, respiratory burst and CD18 adhesion receptor expression of bovine neutrophils

Domestic Animal Endocrinology
K Van OostveldtC Burvenich

Abstract

Polymorphonuclear neutrophil leukocytes (PMN) play an important role in intramammary defense against infections by Escherichia coli. During mastitis, PMN are confronted with various inflammatory mediators that can modulate their function. In severely diseased cows, increased concentrations of lipopolysaccharide (LPS) and tumor necrosis factor (TNF)-alpha (TNF-alpha) are detected in plasma. Binding of LPS to membrane bound CD14 molecules on monocytes cause release of inflammatory mediators such as TNF-alpha. Because apoptosis of PMN promotes resolution of inflammation and because the LPS and TNF-alpha response in milk and blood is related to the severity of E. coli mastitis, the effect on apoptosis of bovine PMN of increased concentrations LPS and TNF-alpha was studied together with the functionality of apoptotic PMN. Bovine PMN apoptosis, as determined with annexin-V, was induced with high concentrations of either LPS (1000 and 10,000ng/mL) or TNF-alpha (10,000ng/mL) in whole blood following a 6h incubation at 37 degrees C. The apoptosis inducing effect of LPS on PMN was not inhibited following coculture with either anti-bovine TNF-alpha or anti-ovine CD14 monoclonal antibodies. When compared to controls, apoptotic PMN had a si...Continue Reading

References

Jan 1, 1979·Journal of Dairy Science·M J PaapeR E Pearson
Nov 1, 1992·American Journal of Respiratory Cell and Molecular Biology·G CoxM Jordana
Feb 1, 1991·Current Opinion in Immunology·S D Wright
Jan 1, 1988·Free Radical Biology & Medicine·P Bellavite
Jan 1, 1987·Pathology and Immunopathology Research·B Chakravarti, D N Chakravarti
Jan 1, 1986·Methods in Enzymology·C J van Oss
Jun 1, 1993·International Immunology·Y TakedaF Sendo
Dec 1, 1995·Seminars in Cell Biology·J Savill, C Haslett
Jul 1, 1997·Cell Biology and Toxicology·R Schulte-HermannB Grasl-Kraupp
Oct 31, 1998·Oncogene·C Sidoti-de FraisseJ L Vayssière
Oct 3, 1999·Veterinary Immunology and Immunopathology·K Van OostveldtE Van den Eeckhout
Jul 4, 2001·Nature Reviews. Molecular Cell Biology·R A Lockshin, Z Zakeri

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Citations

Oct 5, 2011·Journal of Mammary Gland Biology and Neoplasia·Juan J LoorMassimo Bionaz
Jul 1, 2009·Animal : an International Journal of Animal Bioscience·A E IbeaghaX Zhao
Oct 28, 2008·Veterinary Immunology and Immunopathology·Christophe R CasteleynWim Van den Broeck
Jan 18, 2015·Veterinary Research·Alice Maria Melville Paiva Della LiberaMaiara Garcia Blagitz
Feb 16, 2015·Journal of Dairy Science·M G BlagitzA M M P Della Libera
Apr 15, 2009·Research in Veterinary Science·Petr SlamaTereza Langrova
Sep 5, 2006·Comparative Immunology, Microbiology and Infectious Diseases·Z Sladek, D Rysanek
Mar 7, 2006·Veterinary Immunology and Immunopathology·M RambeaudG M Pighetti
Apr 22, 2003·Journal of Dairy Science·H DosogneC Burvenich
Aug 20, 2019·The Journal of Dairy Research·Natalia G C VasileiouGeorge C Fthenakis
Apr 2, 2020·Journal of Dairy Science·F N SouzaA M M P Della Libera
Mar 7, 2017·Journal of Animal Science and Biotechnology·Alea AgrawalJuan J Loor
Sep 29, 2019·Animals : an Open Access Journal From MDPI·Angeliki I KatsafadouIlektra A Fragkou

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