Effect of aprepitant on kynurenine to tryptophan ratio in cART treated and cART naïve adults living with HIV.

Medicine
Sergei SpitsinSteven D Douglas

Abstract

Changes in tryptophan metabolism affect human physiology including the immune system, mood, and sleep and are associated with human immunodeficiency virus (HIV) pathogenesis. This study investigates whether the treatment of HIV-infected individuals with the neurokinin-1 receptor antagonist, aprepitant, alters tryptophan metabolism.This study utilized archival samples from 3 phase 1B clinical trials "Anti-HIV Neuroimmunomodulatory Therapy with Neurokinin-1 Antagonist Aprepitant"-2 double-blinded, placebo-controlled, and 1 open-label study. We tested samples from a total of 57 individuals: 26 combination antiretroviral therapy (cART) naïve individuals receiving aprepitant, 19 cART naïve individuals receiving placebo, and 12 individuals on a ritonavir-containing cART regimen receiving aprepitant. We evaluated the effect of aprepitant on tryptophan metabolism by measuring levels of kynurenine and tryptophan in archival plasma samples and calculating the kynurenine to tryptophan ratio.Aprepitant treatment affected tryptophan metabolism in both cART treated and cART naïve individuals with more profound effects in patients receiving cART. While aprepitant treatment affected tryptophan metabolism in all HIV-infected patients, it only s...Continue Reading

References

Jan 1, 1989·Archives of General Psychiatry·S J SchleiferM Stein
Nov 1, 1996·The American Journal of Psychiatry·C G LyketsosG J Treisman
Sep 1, 1996·Annals of Epidemiology·K Page-ShaferW Winkelstein
Jul 1, 1999·JAMA : the Journal of the American Medical Association·R GlaserB Natelson
Mar 23, 2001·JAMA : the Journal of the American Medical Association·J R IckovicsUNKNOWN HIV Epidemiology Research Study Group
Oct 19, 2001·Seminars in Clinical Neuropsychiatry·C L Raison, A H Miller
Oct 3, 2002·The American Journal of Psychiatry·Dwight L EvansJohn M Petitto
Oct 16, 2002·Journal of Psychosomatic Research·Janice K Kiecolt-Glaser, Ronald Glaser
Oct 31, 2002·Nature Reviews. Drug Discovery·Trevor W Stone, L Gail Darlington
Aug 9, 2005·Biological Psychiatry·Dwight L EvansWilliam J Valvo
Oct 28, 2005·The New England Journal of Medicine·J John Mann
May 9, 2006·International Journal of Methods in Psychiatric Research·Sandra E SephtonDavid Spiegel
Jun 4, 2008·Psychosomatic Medicine·Jane Leserman
Jun 11, 2008·Psychosomatic Medicine·Gail Ironson, H'Sien Hayward
Oct 16, 2010·Psychosomatic Medicine·Tami BentonDwight L Evans
Oct 20, 2010·Brain, Behavior, and Immunity·Joshua BlumeDwight L Evans
Mar 1, 1996·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·T L PattersonUNKNOWN HIV Neurobehavioral Research Center (HNRC) Group
Dec 3, 2013·Sleep·Emiliangelo RattiEmilio Merlo-Pich
May 28, 2016·Journal of Translational Medicine·Jeffrey S BarrettSteven D Douglas

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