Effect of aprotinin on activated clotting time, whole blood and plasma heparin measurements

The Annals of Thoracic Surgery
G J DespotisD G Lappas

Abstract

Twenty cardiac surgical patients requiring cardiopulmonary bypass were enrolled in this study designed to evaluate the effect of aprotinin on activated clotting time (kaolin and celite), whole blood, and laboratory-based plasma (anti-Xa) heparin measurements. Whole blood heparin measurements were not different (p = 0.98) between aprotinin-treated (3.2 +/- 2.8 U/mL) and control (3.2 +/- 3.0 U/mL) specimens. Plasma anti-Xa heparin measurements were also not different (p = 0.95) between aprotinin-treated (2.7 +/- 2.5 U/mL) and control (2.8 +/- 2.5 U/mL) specimens. The relationship between whole blood (plasma equivalent) and plasma heparin measurements was similar (p = 0.1) in the presence (slope, 1.04; r2 = 0.89) or absence (slope, 1.11; r2 = 0.89) of aprotinin. In contrast to weak correlations between celite (r = 0.50) or kaolin (r = 0.53) activated clotting time values, whole blood heparin measurements correlated well (r = 0.93) with plasma heparin measurements during cardiopulmonary bypass in the presence of aprotinin. These findings indicate that whole blood heparin measurements are unaffected by aprotinin and correlate well with plasma anti-Xa heparin measurements even in the presence of aprotinin. Therefore, the automated pr...Continue Reading

References

Mar 1, 1976·Thrombosis Research·A N TeienU Abildgaard
Dec 1, 1992·The Annals of Thoracic Surgery·D M CosgroveF D Loop
Feb 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
Oct 1, 1992·The Journal of Thoracic and Cardiovascular Surgery·J S WangR B Karp
Dec 15, 1989·Thrombosis Research·F EspañaJ Gilabert
Apr 1, 1986·Anesthesiology·E F Anderson
Jun 1, 1984·The Annals of Thoracic Surgery·A H SabbaghW Gabrhel
Apr 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
Apr 1, 1994·Journal of Cardiothoracic and Vascular Anesthesia·R J HuyzenW van Oeveren
Feb 1, 1993·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·H P WendelH E Hoffmeister
Nov 1, 1993·The Annals of Thoracic Surgery·R D DowlingJ M Armitage

❮ Previous
Next ❯

Citations

Jun 20, 1998·British Journal of Haematology·S Bannan, P G Martin
Mar 1, 1996·The Annals of Thoracic Surgery·G J DespotisD G Lappas
Aug 1, 1995·The Annals of Thoracic Surgery·L T GoodnoughT B Ferguson
Mar 20, 2008·Anesthesia and Analgesia·Michael P Eaton
Feb 18, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L Shore-LessersonM DePerio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.