Effect of Aqueous Cream BP on human stratum corneum in vivo

The British Journal of Dermatology
M Tsang, R H Guy

Abstract

Aqueous Cream BP is widely prescribed to patients with eczema to relieve skin dryness. The formulation contains sodium lauryl sulphate (SLS), a chemical that is a known skin irritant and a commonly used excipient in personal care and household products. The chronic effects of Aqueous Cream BP application on skin barrier function have not been determined. To characterize and assess skin barrier function of healthy skin after application of Aqueous Cream BP and to study the physical effects of the formulation on the stratum corneum (SC). The left and right volar forearms of six human volunteers were each separated into treated and control sides. The treated sides of each forearm were subjected to twice daily applications of Aqueous Cream BP for 4 weeks at the end of which concomitant tape stripping and transepidermal water loss (TEWL) measurements were made. The untreated sides of the forearms were not exposed to any products containing SLS during the study period. Changes in SC thickness, baseline TEWL and rate of increase in TEWL during tape stripping were observed in skin treated with Aqueous Cream BP. The mean decrease in SC thickness was 1·1 μm (12%) (P = 0·0015) and the mean increase in baseline TEWL was 2·5 g m⁻² h⁻¹ (20%)...Continue Reading

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Citations

Sep 26, 2012·Dermatology Research and Practice·M Catherine Mack Correa, Judith Nebus
Sep 8, 2012·Clinical, Cosmetic and Investigational Dermatology·Jasmina Djokic-GallagherValerie Hart
Apr 18, 2012·Clinics in Dermatology·Marie Lodén
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Mar 7, 2012·The Journal of Dermatological Treatment·Kam-Lun Ellis HonTing Fan Leung
Nov 14, 2012·Biomaterials·Xiaojuan KhooDaniel S Kohane
Jun 9, 2016·International Journal of Nursing Studies·Jan Kottner, Christian Surber
Jan 14, 2017·JBI Database of Systematic Reviews and Implementation Reports·Tanja KlotzJohn Greenwood
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Aug 10, 2012·British Journal of Nursing : BJN·Garry Cooper
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Oct 22, 2019·The Journal of Dermatological Treatment·Michael J CorkGraham S Ogg
Apr 17, 2019·Dermatologic Therapy·Caroline FornerSonja Ständer

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