Effect of Aqueous Extract of F. capensis Leaves and Its Combination with C. aconitifolius Leaves on Essential Biochemical Parameters of Phenylhydrazine-Induced Anemic Rats

Journal of Experimental Pharmacology
Obiajulu Christian EzeigweKingsley Kelechi Asogwa

Abstract

Ficus capensis Moraceae and Cnidoscolus aconitifolius Euphorbiaceae leaves have been used separately in traditional medical practice to treat different ailments, of which anemia is one. This study aims to evaluate the effect of F. capensis and C. aconitifolius on hepatic, renal parameters and oxidative stress of phenylhydrazine-induced anemic rats. Thirty-five rats were randomized into seven groups (A-G) of five rats each. Groups A and B served as the normal control and anemic control, respectively, while Groups C, D, E, F, and G were treated with a standard drug (vitamin B12), 200mg/kg bw. aqueous extract of F. capensis, 400mg/kg b.w. aqueous extract of F. capensis, 200mg/kg bw. of a combination of aqueous extract of F. capensis and C. aconitifolius and 400mg/kg bw. of a combination of aqueous extract of F. capensis and C. aconitifolius, respectively. The biochemical analysis (liver and kidney function analysis, oxidative stress) was carried out using standard diagnostic techniques. The results showed that there was significant decrease (p<0.05) in the values obtained for Aspartate Transaminase (AST), alanine Transaminase (ALT), Alkaline Phosphatase (ALP), total bilirubin, urea, creatinine, potassium ion, Total Cholesterol (TC...Continue Reading

References

Jan 1, 1978·Methods in Enzymology·J A Buege, S D Aust
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Makiya NishikawaMitsuru Hashida

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