Effect of arginine vasopressin in the nucleus raphe magnus on antinociception in the rat

Peptides
Jun YangBao-Cheng Lin

Abstract

Previous work has shown that arginine vasopressin (AVP) regulates antinociception through brain nuclei rather than the spinal cord and peripheral organs. The present study investigated the nociceptive effect of AVP in the nucleus raphe magnus (NRM) of the rat. Microinjection of AVP into the NRM increased pain threshold in a dose-dependent manner, while local administration of AVP-receptor antagonist-d(CH2)5Tyr(Et)DAVP decreased the pain threshold. Pain stimulation elevated AVP concentration in the NRM perfuse liquid. NRM pretreatment with AVP-receptor antagonist completely reversed AVP's effect on pain threshold in the NRM. The data suggest that AVP in the NRM is involved in antinociception.

References

Oct 1, 1978·The Journal of Comparative Neurology·J L Antunes, E A Zimmerman
Feb 1, 1978·Clinical Endocrinology·K S KendlerD A Fisher
Jan 1, 1985·Journal of Neuroscience Methods·R D MyersL A Gurley-Orkin
Dec 14, 1968·British Medical Journal·H AzizE Miller
Jul 1, 1984·Peptides·J H Kordower, R J Bodnar
Sep 1, 1996·Progress in Neurobiology·J Sandkühler

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Citations

Aug 22, 2009·Neuroscience Letters·Kerstin RoeskaHenri Doods
Nov 22, 2008·Peptides·Jun YangBao-Cheng Lin
Mar 22, 2008·Brain Research Bulletin·Jun YangBao-Chen Lin
Aug 1, 2007·Neuropeptides·Jun YangBao-Cheng Lin
Apr 11, 2007·Peptides·Jun YangBao-Chen Lin
Sep 12, 2012·Peptides·Jun YangJing-Cheng Wang
May 28, 2010·The International Journal of Neuroscience·Xi-Jian ZhouBao-Cheng Lin

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