Effect of Argyreia speciosa root extract on cafeteria diet-induced obesity in rats.

Indian Journal of Pharmacology
Shiv KumarM Raghavendra Rao

Abstract

To evaluate the antiobesity effects of the ethanolic extract of Argyreia speciosa roots in rats fed with a cafeteria diet (CD). Obesity was induced in albino rats by feeding them a CD daily for 42 days, in addition to a normal diet. Body weight and food intake was measured initially and then every week thereafter. On day 42, the serum biochemical parameters were estimated and the animals were sacrificed with an overdose of ether. The, liver and parametrial adipose tissues were removed and weighed immediately. The liver triglyceride content was estimated. The influence of the extract on the pancreatic lipase activity was also determined by measuring the rate of release of oleic acid from triolein. The body weight at two-to-six weeks and the final parametrial adipose tissue weights were significantly lowered (P < 0.01 and P < 0.05, respectively) in rats fed with the CD with Argyreia speciosa extract 500 mg/kg/day as compared to the CD alone. The extract also significantly reduced (P < 0.01) the serum contents of leptin, total cholesterol, low density lipoprotein (LDL), and triglycerides, which were elevated in rats fed with CD alone. In addition, the extract inhibited the induction of fatty liver with the accumulation of hepatic ...Continue Reading

References

Jun 13, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·S LinX F Huang
Dec 25, 2002·Journal of Ethnopharmacology·A B GokhaleM N Saraf
Sep 11, 2004·Archives of Pharmacal Research·Se Na YunSung Hyun Chung
Jan 9, 2007·Lancet·Raj S Padwal, Sumit R Majumdar
Oct 2, 2009·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·C GargM Garg
Nov 27, 2009·Postgraduate Medicine·Xavier Pi-Sunyer
Jan 1, 2008·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·P V HabbuS K Das
Jun 5, 2010·Indian Journal of Pharmacology·R S BachhavC D Upasani

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Citations

Oct 1, 2013·Journal of Natural Medicines·Lorisa S TeixeiraEmerson S Lima
Sep 15, 2015·Stress : the International Journal on the Biology of Stress·Carla de OliveiraIraci L S Torres
Aug 21, 2013·Saudi Journal of Biological Sciences·Item J AtangwhoMariam Ahmad

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Methods Mentioned

BETA
Enzyme-Linked Immunosorbent Assay

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