Abstract
We investigated the effects of chronic treatment with arotinolol, a beta-blocker with weak alpha-blocking potency, on hemodynamics and plasma levels of catecholamines and atrial natriuretic peptide (ANP) at rest and during stress in spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats. At rest, arotinolol treatment decreased mean arterial pressure (MAP), cardiac index (CI) and heart rate (HR), with no changes in total peripheral resistance index or regional hemodynamics in SHR. Acute stress caused more remarkable hemodynamic changes in SHR. During stress, arotinolol decreased MAP, CI and HR, and reduced myocardial and skeletal muscle flow and splanchnic, renal, cerebral and cutaneous vascular resistance in SHR. Arotinolol's effects were much less in WKY. Stress also increased the plasma catecholamine and ANP levels in SHR. Arotinolol raised these hormones in both strains at rest and in SHR during stress. Thus, arotinolol treatment exerted greater suppressive effects on the resting and stressed hemodynamics in SHR, with associated increases in the plasma catecholamine and ANP levels.
References
Nov 1, 1976·The American Journal of Medicine·J V Levy
Sep 1, 1978·Journal of Pharmaceutical Sciences·Y HaraT Hibino
Sep 1, 1979·Acta Physiologica Scandinavica·E NoressonP Thorén
May 1, 1988·Journal of Cardiovascular Pharmacology·R C TsaiY S Lee
Dec 17, 1985·Biochemical and Biophysical Research Communications·T ImadaT Inagami
Feb 27, 1987·Biochemical and Biophysical Research Communications·J KatoK Tanaka
Sep 1, 1987·Hypertension·J P StaschF Morich
Feb 1, 1988·Circulation Research·H Ruskoaho, J Leppäluoto
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·K PetterssonS R Bloom
Jun 28, 1985·Biochemical and Biophysical Research Communications·K HorkýM Cantin
Apr 1, 1987·Hypertension·J YamamotoT Natsume
Nov 1, 1985·Hypertension·J YamamotoM Ikeda
Nov 1, 1983·Japanese Heart Journal·N TakekoshiA Hashimoto
Feb 1, 1984·Journal of Hypertension·S A Lundin, M I Hallbäck-Nordlander
Jan 1, 1984·Clinical and Experimental Hypertension. Part A, Theory and Practice·J Weissinger
Jan 1, 1980·Clinical and Experimental Hypertension : CHE·C RicherJ F Giudicelli
Jun 1, 1981·Acta Physiologica Scandinavica·S E RickstenP Thorén