PMID: 9440242Jan 24, 1998Paper

Effect of arsenite, arsenate, and the herbicide monosodium methyl arsonate (MSMA) on hepatic metallothionein expression and lipid peroxidation in channel catfish

Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology
D SchlenkK M Chan

Abstract

Arsenic exerts its toxicity by the generation of reactive oxygen intermediates which caused lipid peroxidation and cellular damage. Metallothioneins (MTs) have been shown to be induced by oxidative stress and act as scavengers of reactive oxygen intermediates. Thus, hepatic MT was examined in channel catfish treated with the herbicide monosodium methyl arsonate (MSMA) and compared to equal doses of trivalent and pentavalent arsenic. Fish were exposed to 0.01, 0.1, and 1.0 mg/L of each compound for 1 week by static renewal. Hepatic MT was measured by the cadmium/hemoglobin (Cd/Hb) saturation assay, ELISA using antibodies raised against the first 10 amino acids of piscine MT, and Northern blot analysis using a cDNA encoding winter flounder hepatic MT. Cd/Hb and ELISA measurements of low molecular weight fractions from the hepatic cytosolic component of fish exposed to MSMA revealed a dose dependent increase in MT. MTs and MT mRNA of fish receiving the 1.0 mg/L dose were significantly induced vs control. Responses to arsenate exposure were more variable, but showed a trend toward a dose-dependent induction of MT and MT mRNA. MT mRNA and protein also showed a dose-dependent increase with arsenite exposure with no significant differ...Continue Reading

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Citations

Aug 10, 2007·Archives of Environmental Contamination and Toxicology·Julieta WernerAlison Yarmill
Mar 9, 2013·Biological Trace Element Research·Jesús Alberto Valentino-ÁlvarezLaura Fernández-Bringas
Apr 8, 2003·Toxicology·Xing Hui ZhengA Jay Gandolfi
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Apr 4, 2014·Diseases of Aquatic Organisms·Zeliha Selamoglu TalasIbrahim Orun
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Sep 1, 2014·Ecotoxicology and Environmental Safety·Jessica MierzejewskiPeter van den Hurk
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Aug 25, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Lissandra GlusczakVânia Lucia Loro
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Jan 24, 2006·Ecotoxicology and Environmental Safety·Anirban Bhattacharya, Shelley Bhattacharya

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