PMID: 12778878Jun 5, 2003Paper

Effect of arterial pressure and age on renal function, The "Care for the Kidney" study

Nefrología : publicación oficial de la Sociedad Española Nefrologia
J OlivaresF J Morales-Olivas

Abstract

The kidney is one of the principal target organs of hypertension. The mechanism by which hypertension damages the kidney and the relative contribution of high blood pressure to the progression of renal failure remains incompletely defined. The clinical quantification of renal function is usually thought to require determination of plasma clearance of endogenous creatinine (ClCr), an impractical test for epidemiological evaluation. For this reason several formulae have been proposed to estimate the ClCr from the serum creatinine concentration, such as sex, age, and body weight. The most often used formula is the one proposed by Crockroft and Gault in 1976. To determine the prevalence of loss of renal function and the influence of hypertension and age on this loss in hypertensive and normotensive patients. An observational, cross-sectional comparative study was carried out. 3,420 patients (1,171 normotensive and 2,249 hypertensive) were studied. Average age was 70 years (19.4% of patients < 65 years; 23.3% > 75 years). 98.1 of hypertensive patients were treated with drugs, 26.7% of them with more than one drug. 27.9% of treated patients achieved blood pressure control (< 140-90 mm Hg). The level of renal function was estimated by...Continue Reading

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