Effect of ArtinM on Human Blood Cells During Infection With Paracoccidioides brasiliensis

Frontiers in Microbiology
Luciana P RuasMaria-Heloisa S L Blotta

Abstract

Infections caused by fungi are prominent in our environment and can be potentially fatal. paracoccidioidomycosis (PCM), caused by fungi of the Paracoccidioides genus, is the most frequent systemic mycosis in Brazil and the main cause of death among immunocompetent individuals. The antifungal therapy for PCM is usually effective but side effects and relapses are often reported. The latter could be avoided with alternative or complementary therapies aimed at boosting the immune response to combat this pathogen. Recent reports have pointed at the importance of an effective cellular immune response, with the participation of Th1 cells, in the resistance to and control of Paracoccidioides infection. The ArtinM lectin, extracted from jackfruit (Artocarpus heterophyllus) seeds, exhibits immunomodulatory activity against several intracellular pathogens, including Paracoccidioides brasiliensis, by promoting the development of a Th1 immune response. The aim of this work was to characterize the effect of ArtinM on peripheral blood cells of patients with PCM and on those of control individuals infected with fungal yeasts cells in vitro. Our results demonstrate that ArtinM activates human neutrophils in vitro, leading to an increase in cyto...Continue Reading

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J M Farber
Apr 1, 1987·Revista Da Sociedade Brasileira De Medicina Tropical·M FrancoN G Mota
Dec 1, 1985·Mycopathologia·S S KashinoL M Singer-Vermes
Apr 1, 1993·Clinical Microbiology Reviews·E BrummerA Restrepo
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·V L Calich, S S Kashino
Aug 28, 1998·Research in Immunology·V L CalichE Burger
Dec 30, 1999·Journal of Leukocyte Biology·K A Roebuck, A Finnegan
Nov 14, 2001·The Journal of Biological Chemistry·Jean da Silva Correia, Richard J Ulevitch
Feb 6, 2002·Trends in Microbiology·M Ines Borges-WalmsleyAdrian R Walmsley
Aug 7, 2002·The Journal of Experimental Medicine·Gordon D BrownSiamon Gordon
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philip R TaylorSimon Y C Wong
Mar 26, 2003·Microbes and Infection·Sueli A CalviAngela M V C Soares
Apr 30, 2003·The Journal of Experimental Medicine·Gordon D BrownSiamon Gordon
Dec 4, 2003·International Archives of Allergy and Immunology·A N MorenoM C Roque-Barreira
Dec 9, 2003·Nature Reviews. Immunology·Luigina Romani
May 27, 2004·European Journal of Immunology·Andrew S CowburnEdwin R Chilvers
Jul 2, 2004·Glycobiology·Nathan Sharon, Halina Lis
Nov 2, 2005·Biochimica Et Biophysica Acta·Gabriela Pereira-da-SilvaMaria Cristina Roque-Barreira
Feb 4, 2006·Vaccine·Clarissa R TeixeiraManoel Barral-Netto
Feb 14, 2006·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Eduardo BagagliMarcello Franco
Apr 19, 2006·The Journal of Infectious Diseases·Alieke G VonkBart Jan Kullberg
Oct 19, 2006·Cytokine·Ronei Luciano Mamoni, Maria Heloisa Souza Lima Blotta
Jun 27, 2008·Acta Tropica·Eliana A G ReisMitermayer G Reis
Sep 9, 2008·Mycopathologia·Vera Lúcia Garcia CalichAdriana Pina
Nov 22, 2008·Biochemical Society Transactions·Nathan Sharon

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Citations

Mar 19, 2019·Journal of Immunology Research·Juliana Carvalho de Quaglia E SilvaLuciane Alarcão Dias-Melicio
Mar 26, 2020·PloS One·Patricia A A BuranelloConstance Oliver
Oct 12, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Fernando Cezar-Dos-SantosEiko Nakagawa Itano

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Methods Mentioned

BETA
density gradient centrifugation
ELISA
FACS
flow cytometry
FCS
PMA

Software Mentioned

FCS Express
GraphPad InStat
GraphPad

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