Jan 1, 1976

Effect of ascaris extract applied intravenously, on segment bronchus and the influence of ipsilateral vagus blockade

Respiration; International Review of Thoracic Diseases
I ZimmermannW T Ulmer

Abstract

Respiratory hypersensitivity and systemic effects after local application of Ascaris suum extract on the segmental bronchus and after its intravenous infusion are studied on four boxer dogs. Influence of ipsilateral vagus blockade on the respiratory hyperreactivity after intrabronchial application of ascaris was also investigated on the same dogs. Ascaris extract was applied in liquid form directly through a catheter into the right segmental bronchus. Egg albumin was applied in the same way for control. Local application of ascaris was repeated after ipsilateral central vagus blockade and once more after recovering vagus effect by lavage. At the end of the experiments ascaris extract was infused intravenously. The parameters studied were: deltaP(oes) mm Hg/100 ml TV (as a measurement of flow resistance in the airways), respiratory rates, arterial blood gases and pH, heart frequency, systemic blood pressure and histamine concentration per milliliter of plasma. All the animals presented a remarkable respiratory distress with local ascaris application, which could be clearly avoided with ipsilateral central vagus blockade. This respiratory hyperreactivity was not observed after intravenous infusion of ascaris extract, but a signif...Continue Reading

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Mentioned in this Paper

Histamine Measurement
Ascaris suum
Entire Segmental Bronchus
Tidal Volume
Dioxygen
Airway Resistance
Diastolic Blood Pressure
ALB
Bronchi
Vagus Nerve Structure

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