Effect of ascorbic acid deficiency on primary and reparative dentinogenesis in non-ascorbate-synthesizing ODS rats

Archives of Oral Biology
M OgawaraH Suda

Abstract

Ascorbic acid is essential to the biosynthesis of collagen, the major organic matrix component of dentine. The ODS rat is a mutant strain of Wistar rat characterized by hereditary lack of L-gulono-gamma-lactone oxidase and thus is unable to synthesize ascorbic acid. ODS rats were given an ascorbic acid-free diet to investigate how ascorbic acid deficiency affects dentine formation in vivo. Histomorphometric analysis on their growing molars and incisors showed a significant reduction in both size and mineral apposition rate of dentine, as revealed by contact microradiography and fluorescent time-marking, respectively. A similar reduction in bone formation was simultaneously demonstrated in the mandible, confirming the previously reported osteopathic effects of ascorbic acid deficiency. When pulp inflammation was induced in lower first molars by making unsealed pulp exposures, specimens from control animals showed continuous deposition of an osteodentine-like tissue in the radicular pulp chamber; this type of mineralized tissue formation was greatly reduced in ascorbic acid-deprived animals. These results indicate that ascorbic acid deficiency hampers dentine formation under both physiological and pathological conditions of the d...Continue Reading

References

Jul 5, 1979·The New England Journal of Medicine·D J ProckopN A Guzman
Jan 1, 1992·Brain Research Bulletin·A GhaharyS K Malhotra
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J E Russell, P R Manske
Jan 1, 1991·The Journal of Nutrition·C S Johnston, S N Huang
Jan 1, 1991·Calcified Tissue International·T TsunenariT Fujita
Oct 1, 1990·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·H Padh
Aug 1, 1989·Shika Kiso Igakkai zasshi = Japanese journal of oral biology·H Amano
Dec 1, 1987·Archives of Dermatology·S R PinnelD Darr
Apr 1, 1988·The Journal of Investigative Dermatology·J C GeesinS R Pinnell
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·F L StassenS Udenfriend
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S MuradS R Pinnell
Apr 15, 1984·Experientia·Y MizushimaS Makino
Jul 1, 1995·Japanese Journal of Pharmacology·A TogariS Matsumoto
Apr 1, 1995·Archives of Oral Biology·K MiyajimaT Iizuka
Jan 1, 1995·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·F VaxmanJ F Grenier

❮ Previous
Next ❯

Citations

Jun 19, 2008·Journal of Materials Science. Materials in Medicine·R VaniS Narayana Kalkura
Sep 6, 2005·Journal of Dentistry·E Koliniotou-Koumpia, D Tziafas
Jul 20, 2013·International Journal of Paediatric Dentistry·Liang SunWeidong Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.