Effect of asiaticoside on hypertrophic scar in the rabbit ear model

Journal of Cutaneous Pathology
Xie Ju-LinHuang Yong

Abstract

Previous observations suggested that asiaticoside had a possible antiscaring effect. However, the precise pathological mechanism still remain unknown. We questioned whether asiaticoside might alleviate the formation of hypertrophic scar by affecting the expression of Transform growth factor beta (TGF-beta)/Smad signaling. To investigate the effect of asiaticoside on the expression of TGF-beta/Smad signaling in the rabbit ear model of hypertrophic scar and to clarify the mechanism of asiaticoside on the scar treatment. The rabbit model with hypertrophic scar was created and applied topically with a low-dose (0.5%) or high-dose (1%) asiaticoside three times daily for 1, 2 or 3 months and then we examined the changes of macroscopic and histopathologic characteristics of scars, and the expression of TGF-beta(1) and Smad protein was studied by applying reverse transcription-polymerase chain reaction and western blotting. Asiaticoside could remarkably alleviate the scar in the rabbit ear model. Western blotting showed that the asiaticoside could decrease TGF-beta(1) expression, and further study revealed that asiaticoside could remarkably enhance the expression of inhibitory Smad7, but it had no effect on the expression of Smad2. Asi...Continue Reading

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Citations

Dec 8, 2010·Aesthetic Plastic Surgery·Alan D Widgerow
May 28, 2013·Aesthetic Plastic Surgery·Apirag ChuangsuwanichSirichai Kamnerdnakta
Jul 2, 2010·Nutrition Reviews·Angela C B FerreiraLydia M Ferreira
Jul 17, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Xiao Song LiuHong Hua
Jan 19, 2011·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Heloise GisquetFrançois Guillemin
Mar 3, 2011·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan D Widgerow
Sep 4, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jeong-Hyun LeeJong-Chul Park
May 28, 2013·Aesthetic Surgery Journal·Wang XiaoxueXiao Zhibo
Feb 12, 2013·Journal of Clinical Orthodontics : JCO·Robert G Keim
Oct 13, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Kamonwan JenwitheesukPalakorn Surakunprapha
Mar 23, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Xiguang FengFanyu Wu

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