Effect of asimadoline, a kappa opioid agonist, on pain induced by colonic distension in patients with irritable bowel syndrome

Alimentary Pharmacology & Therapeutics
M DelvauxJ Frexinos

Abstract

Visceral hypersensitivity plays a major role in irritable bowel syndrome pathophysiology. Opioid kappa receptors on afferent nerves may modulate it and be the target for new irritable bowel syndrome treatments. This study evaluated the effect of the kappa opioid agonist asimadoline on perception of colonic distension and colonic compliance in irritable bowel syndrome patients. Twenty irritable bowel syndrome female patients (Rome II criteria; 40 +/- 13 years) and hypersensitivity to colonic distension (Pain threshold < or = 32 mmHg) were included in a randomized double-blind cross-over trial comparing the effect of a single oral dose of asimadoline 0.5 mg or placebo on sensory thresholds (defined as a constant and sustained sensation) elicited by left colon phasic distension (5 mmHg steps, 5 min) up to a sensation of abdominal pain. Colonic compliance was compared by the slope of the pressure-volume curves. On asimadoline, pain threshold (mean +/- s.d.) (29.8 +/- 7.2 mmHg) was higher than on placebo (26.3 +/- 7.8 mmHg), difference not statistically significant (P = 0.1756, ANOVA). Area under curve of pain intensity rated at each distension step was significantly lower on asimadoline (89.3 +/- 33.9, ANOVA) than on placebo (108.1...Continue Reading

References

May 1, 1990·Gastroenterology·W E WhiteheadM M Schuster
Jun 1, 1990·Gastroenterology·W E WhiteheadM M Schuster
Aug 27, 1985·European Journal of Pharmacology·F Lembeck, J Donnerer
Sep 1, 1994·Digestive Diseases and Sciences·G BassottiW E Whitehead
Jan 1, 1995·Pharmacology & Therapeutics·M Satoh, M Minami
Mar 6, 1999·Pain·J N SenguptaG F Gebhart
Apr 30, 1999·Gastroenterology·E DistruttiJ R Malagelada
Aug 10, 1999·Journal of Clinical Psychopharmacology·B A SprouleE M Sellers
Aug 24, 1999·Gut·W G ThompsonS A Müller-Lissner
Mar 13, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Silvia Delgado-ArosAlan R Zinsmeister
Feb 26, 2004·Statistics in Medicine·UNKNOWN Committee for Proprietary Medicinal Products (CPMP)

❮ Previous
Next ❯

Citations

Aug 8, 2006·Current Gastroenterology Reports·William D Chey, Brooks D Cash
Aug 8, 2006·Current Gastroenterology Reports·Lucinda A HarrisMichael D Crowell
Nov 3, 2005·Nature Clinical Practice. Gastroenterology & Hepatology·Filippo Cremonini, Nicholas J Talley
Dec 1, 2011·The Journal of Pharmacology and Experimental Therapeutics·S Stevens NegusKenner C Rice
Sep 8, 2012·Gastroenterology Research and Practice·Emanuele SinagraMario Cottone
May 16, 2006·Digestive Diseases·Michel M Delvaux, Gérard Gay
Jul 20, 2006·Digestive Diseases·Brian E Lacy, Kirsten Weiser
Oct 3, 2013·The Journal of Clinical Investigation·Michael Camilleri
Jun 23, 2011·Therapeutic Advances in Gastroenterology·Anita Sainsbury, Alexander C Ford
Feb 22, 2012·Clinical and Experimental Gastroenterology·Allen W Mangel, Gareth A Hicks
May 8, 2008·World Journal of Gastroenterology : WJG·Christopher W Hammerle, Christina M Surawicz
Apr 30, 2013·Expert Opinion on Pharmacotherapy·Michael Camilleri
Jun 20, 2013·Expert Opinion on Pharmacotherapy·Baharak MoshireeNicholas Talley
Feb 12, 2011·Expert Review of Gastroenterology & Hepatology·Daniel P HolschneiderEmeran A Mayer
Nov 27, 2009·Expert Opinion on Emerging Drugs·Chander Shekhar, Peter J Whorwell
Jan 31, 2008·Expert Opinion on Investigational Drugs·Richard J Saad, William D Chey
Mar 29, 2014·Expert Opinion on Drug Safety·Shilan MozaffariMohammad Abdollahi
Apr 22, 2008·Expert Opinion on Pharmacotherapy·John T Bassett, Brooks D Cash
Apr 26, 2006·Expert Opinion on Emerging Drugs·Sylvie BradesiEmeran Mayer
Jan 22, 2013·Expert Opinion on Drug Metabolism & Toxicology·Shilan MozaffariMohammad Abdollahi
Sep 3, 2010·Expert Opinion on Investigational Drugs·Allen W Mangel, Valerie Sl Williams
Sep 15, 2010·Expert Opinion on Investigational Drugs·Ola GhaithAla I Sharara
Feb 22, 2011·Gastroenterology Clinics of North America·Robin C Spiller
Feb 22, 2011·Gastroenterology Clinics of North America·Monthira ManeerattanapornWilliam D Chey
Jun 18, 2010·Trends in Pharmacological Sciences·Joseph Y Chang, Nicholas J Talley
Aug 12, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·M Camilleri, V Andresen
Jul 24, 2007·European Journal of Pharmacology·Nadia L Caram-SalasVinicio Granados-Soto
Jul 23, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M H LarssonH Larsson
Mar 12, 2008·Alimentary Pharmacology & Therapeutics·N J TalleyA R Zinsmeister
Oct 1, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·B N FloydA R Zinsmeister
Oct 2, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A W Mangel, S E Fehnel
Dec 13, 2005·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·F CremoniniP J Whorwell
Jan 13, 2006·British Journal of Pharmacology·Alistair D CorbettStewart J Paterson
Feb 7, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L BuenoN J Talley
Aug 22, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M Camilleri
Apr 25, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·V Andresen, M Camilleri
Mar 18, 2011·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y-W TjongC-T Che
May 18, 2012·Alimentary Pharmacology & Therapeutics·B E LacyC Prather
Aug 21, 2015·Alimentary Pharmacology & Therapeutics·Z MujagicA A M Masclee
Jul 24, 2014·Basic & Clinical Pharmacology & Toxicology·Lecia Møller NielsenAsbjørn Mohr Drewes
Dec 17, 2014·Journal of Gastroenterology·Shin FukudoTooru Shimosegawa
Jan 22, 2009·Pain·Charles H Knowles, Qasim Aziz
Jun 4, 2016·Pain Management·Anne E OlesenAsbjørn M Drewes
Sep 29, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Lawrence A SzarkaAlan R Zinsmeister
Aug 25, 2004·Best Practice & Research. Clinical Gastroenterology·Michel Delvaux
Jul 20, 2016·Journal of Neurogastroenterology and Motility·Mohammad H FarzaeiRoja Rahimi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Lawrence A SzarkaA R Zinsmeister
Alimentary Pharmacology & Therapeutics
N J TalleyA R Zinsmeister
© 2022 Meta ULC. All rights reserved