PMID: 6111388Nov 1, 1980Paper

Effect of asparagine, glutamine and insulin on cerebral amino acid neurotransmitters

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
R F ButterworthA Barbeau

Abstract

Treatment of rats with asparagine or glutamine caused substantial increases in glutamine concentrations in cerebellum and medulla oblongata. Insulin treatment caused a diminution of glutamate and GABA in these regions of brain. Since it is now well-established that glutamine is a very efficient precursor of the neurotransmitter pool of glutamate in mammalian brain, treatment with asparagine or glutamine could be of therapeutic (replacement) value in the treatment of neurological disorders such as Friedreich's ataxia, in which cerebral glutamate concentrations have been found to be diminished.

References

Jun 1, 1979·Neurology·D A Stumpf, J K Parks
Jul 20, 1979·Science·R A Hawkins, J F Biebuyck
May 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·R HuxtableA Barbeau
Nov 1, 1976·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·D ShapcottA Barbeau
Nov 1, 1976·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A BarbeauB Lemieux
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Citations

Jan 1, 1982·Archiv für Psychiatrie und Nervenkrankheiten·D ClausH H Kornhuber
Sep 2, 2020·International Journal of Molecular Sciences·Rochelin DalanginRobert E Campbell

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