Effect of aspiration pneumonia-induced sepsis on post-burn cardiac inflammation and function in mice

Surgical Infections
J W HortonBilly Sanders

Abstract

Numerous studies have found that burn injury alters immune function, predisposing the subject to infectious complications. We developed a mouse model of burn injury complicated by either gram-positive or gram-negative infection and hypothesized that post-burn infection would exacerbate the myocardial cytokine responses and contractile dysfunction characteristic of either sepsis alone or burn alone. Adult C57 BL6 mice were given burn injury over 40% of the total body surface area and conventional fluid resuscitation (lactated Ringer's solution, 4 mL/kg/% burn) followed on day 7 by intratracheal administration of 1 x 10(5) cfu of either Streptococcus pneumoniae or Klebsiella pneumoniae or saline. Mice received fluid resuscitation (2 mL of lactated Ringer's intraperitoneally) again after bacterial challenge. Cardiomyocyte cytokine secretion and the contractile function of isolated hearts (Langendorff perfusion) were examined in vitro 24 h after bacterial challenge. Infectious challenge seven days after burn injury exaggerated the inflammatory cytokine responses over those observed with either burn alone or gram-positive or gram-negative infection alone (tumor necrosis factor-alpha: sham, 72 +/- 9 pg/mL; burn alone, 176 +/- 6 pg/mL...Continue Reading

References

Sep 1, 1979·The Journal of Trauma·C C BakerD D Trunkey
Oct 1, 1990·The British Journal of Surgery·B A Pruitt
Nov 1, 1988·Archives of Surgery·K Sittig, E A Deitch
Jan 1, 1987·Annals of Surgery·K Z ShiraniA D Mason
Dec 14, 1995·The New England Journal of Medicine·J G Bartlett, L M Mundy
May 1, 1995·Burns : Journal of the International Society for Burn Injuries·R WurtzM Hanumadass
Apr 1, 1995·The Surgical Clinics of North America·F A Moore, E E Moore
Feb 6, 1998·World Journal of Surgery·B A PruittC W Goodwin
Aug 12, 1998·The Journal of Surgical Research·P W SheeranJ W Horton
Aug 3, 1999·The Journal of Clinical Investigation·S FrantzR A Kelly
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J W HortonB Sanders
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Makiko KobayashiFujio Suzuki
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Junichi SasakiNaoki Aikawa
Dec 5, 2002·Burns : Journal of the International Society for Burn Injuries·Rameshwar L BangImad Al Najjadah
Jun 5, 2003·The Journal of Trauma·John FitzwaterGrant E O'Keefe
Feb 13, 2004·The Journal of Trauma·Kimberly A DavisRavi Shankar
Mar 12, 2004·Surgical Infections·Jureta W HortonBilly Sanders
Mar 31, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Jefferson Lessa de MacedoCleudson Castro
Apr 2, 2004·International Journal of Clinical Practice·Z OzbalkanS Aksaray
Jul 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jureta W HortonJames A Thomas

❮ Previous
Next ❯

Citations

Mar 30, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Qun S ZangFiemu E Nwariaku
Oct 2, 2009·Clinics in Plastic Surgery·Robert Cartotto
Oct 31, 2015·Burns : Journal of the International Society for Burn Injuries·Sheng LiuYong-Jie Wang
Apr 2, 2008·Burns : Journal of the International Society for Burn Injuries·Z BakB Janerot-Sjoberg
Mar 27, 2012·Journal of Burn Care & Research : Official Publication of the American Burn Association·Mark P V BegienemanPaul A J Krijnen
Oct 19, 2013·Experimental and Therapeutic Medicine·Yongqiang FengHongjie Duan
Feb 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sara VianelloSabine de la Porte
Jun 23, 2018·Journal of Burn Care & Research : Official Publication of the American Burn Association·William AlexanderHeather Cleland
Apr 28, 2017·Journal of Burn Care & Research : Official Publication of the American Burn Association·H Ibrahim KorkmazHans W M Niessen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.