Effect of atenolol on heart rate, arrhythmias, blood pressure, and dynamic left ventricular outflow tract obstruction in cats with subclinical hypertrophic cardiomyopathy

Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology
Bethany L JacksonLinda B Lehmkuhl

Abstract

To investigate the negative chronotropic, antiarrhythmic, and obstruction-relieving effects of atenolol in cats with subclinical hypertrophic cardiomyopathy (HCM). Seventeen cats with HCM. Results for echocardiography, electrocardiography, Doppler blood pressure, and 24 h Holter monitoring were compared in cats before and 2-4 weeks after atenolol therapy (6.25-12.5 mg PO q 12 h). The left ventricular outflow tract maximum velocity (LVOT Vmax) decreased after atenolol administration (mean Vmax pre-treatment 3.3 m/s ± 1.8 m/s; post-treatment 1.6 m/s ± 1.0 m/s, p < 0.0001). Heart rate (HR) decreased after atenolol for all HR modalities. The total number of ventricular origin complexes (TotVent) and ventricular premature complexes (VPCs) decreased after atenolol. The VPCs decreased from a geometric mean of 61 complexes/24 h (range, 11-620 complexes/24 h) to 15 complexes/24 h (range, 1-1625 complexes/24 h) (p < 0.0001). Murmur grade decreased after atenolol from a median grade of 3/6 to 2/6 (p < 0.0001). The systolic blood pressure did not change (mean pre-treatment 130 mmHg ± 16 mmHg, mean post-treatment 123 mmHg ± 20 mmHg, p = 0.2). Atenolol decreases HR, murmur grade, and LVOT obstruction, and to a lesser degree, frequency of ven...Continue Reading

References

Jul 20, 2002·Journal of the American Veterinary Medical Association·John E RushDonald J Brown
Mar 3, 2004·Journal of the American Veterinary Medical Association·Alan W Spier, Kathryn M Meurs
Mar 1, 2005·Journal of the American College of Cardiology·A Selcuk AdabagBarry J Maron
Feb 25, 2006·Journal of Veterinary Internal Medicine·Jonathan A Abbott, Heidi N MacLean
Jun 8, 2007·Journal of Veterinary Internal Medicine·S BrownUNKNOWN American College of Veterinary Internal Medicine
Jan 3, 2008·American Journal of Veterinary Research·John M MacgregorLisa M Freeman
May 1, 2005·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Karsten E Schober, Imke Maerz
May 22, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Sofia HanåsBodil Ström Holst
Jun 15, 2011·Research in Veterinary Science·B A MaranO L Nelson
May 21, 2013·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Karsten E SchoberJohn D Bonagura
Dec 4, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Bethany L JacksonDarcy B Adin

❮ Previous
Next ❯

Citations

Apr 4, 2020·Journal of Veterinary Internal Medicine·Virginia Luis FuentesJoshua A Stern
Apr 23, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Y FujiiK Orito
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.