Abstract
To investigate the negative chronotropic, antiarrhythmic, and obstruction-relieving effects of atenolol in cats with subclinical hypertrophic cardiomyopathy (HCM). Seventeen cats with HCM. Results for echocardiography, electrocardiography, Doppler blood pressure, and 24 h Holter monitoring were compared in cats before and 2-4 weeks after atenolol therapy (6.25-12.5 mg PO q 12 h). The left ventricular outflow tract maximum velocity (LVOT Vmax) decreased after atenolol administration (mean Vmax pre-treatment 3.3 m/s ± 1.8 m/s; post-treatment 1.6 m/s ± 1.0 m/s, p < 0.0001). Heart rate (HR) decreased after atenolol for all HR modalities. The total number of ventricular origin complexes (TotVent) and ventricular premature complexes (VPCs) decreased after atenolol. The VPCs decreased from a geometric mean of 61 complexes/24 h (range, 11-620 complexes/24 h) to 15 complexes/24 h (range, 1-1625 complexes/24 h) (p < 0.0001). Murmur grade decreased after atenolol from a median grade of 3/6 to 2/6 (p < 0.0001). The systolic blood pressure did not change (mean pre-treatment 130 mmHg ± 16 mmHg, mean post-treatment 123 mmHg ± 20 mmHg, p = 0.2). Atenolol decreases HR, murmur grade, and LVOT obstruction, and to a lesser degree, frequency of ven...Continue Reading
References
Dec 1, 1978·Circulation·D J SahnA Weyman
Nov 1, 1995·Circulation·P R FoxB J Maron
Jun 22, 1999·Circulation·M D KittlesonJ A Towbin
Jul 20, 2002·Journal of the American Veterinary Medical Association·John E RushDonald J Brown
Mar 3, 2004·Journal of the American Veterinary Medical Association·Alan W Spier, Kathryn M Meurs
Mar 1, 2005·Journal of the American College of Cardiology·A Selcuk AdabagBarry J Maron
Feb 25, 2006·Journal of Veterinary Internal Medicine·Jonathan A Abbott, Heidi N MacLean
Jun 8, 2007·Journal of Veterinary Internal Medicine·S BrownUNKNOWN American College of Veterinary Internal Medicine
Jan 3, 2008·American Journal of Veterinary Research·John M MacgregorLisa M Freeman
May 1, 2005·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Karsten E Schober, Imke Maerz
May 22, 2009·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Sofia HanåsBodil Ström Holst
Mar 23, 2011·Journal of Veterinary Internal Medicine·S C RiesenJ D Bonagura
Jun 15, 2011·Research in Veterinary Science·B A MaranO L Nelson
May 21, 2013·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Karsten E SchoberJohn D Bonagura
Mar 7, 2014·Journal of Veterinary Internal Medicine·K A BlassJ D Bonagura
Dec 4, 2014·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Bethany L JacksonDarcy B Adin
Citations
Mar 20, 2020·The Journal of Veterinary Medical Science·Keisuke SugimotoYoko Fujii
Apr 4, 2020·Journal of Veterinary Internal Medicine·Virginia Luis FuentesJoshua A Stern
Oct 30, 2019·BMC Veterinary Research·Ryohei SuzukiHidekazu Koyama
Apr 23, 2021·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Y FujiiK Orito
Oct 26, 2021·Journal of Feline Medicine and Surgery·Mark D Kittleson, Etienne Côté