Effect of atherosclerosis on transmural convection an arterial ultrastructure. Implications for local intravascular drug delivery

Arteriosclerosis, Thrombosis, and Vascular Biology
A L BaldwinK March

Abstract

Local infusion of agents through perforated catheters may reduce neointimal formation following vascular angioplasty. Such treatment will succeed only if the drug is retained within the arterial intima long enough to promote repair. Drugs will be dispersed throughout the wall predominantly by transmural convection instead of diffusion if the Peclet number, Pe = J (1-delta f)/P, is greater than unity, where J is the transmural fluid flow per unit surface area and delta(f) and P are the reflection and permeability coefficients to the drug, respectively. Although the targets of local drug delivery will be atherosclerotic vessels, little is known about the transport properties of these vessels. Accordingly, we evaluated the effects of hypercholesterolemia and atherosclerosis on J per unit pressure (hydraulic conductance, Lp) and on ultrastructure in femoral arteries. Measurements were made at 30, 60, and 90 mm Hg in anesthetized New Zealand white rabbits fed a normal diet (n = 6) and after 3 weeks of lipid feeding (n = 19). Atherosclerosis was induced in six lipid-fed animals by air desiccation of a femoral artery. Hydraulic conductance was significantly greater in vessels from hypercholesterolemic than from normal animals and decr...Continue Reading

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Citations

Apr 12, 2011·Annals of Biomedical Engineering·Zhong-Dong Shi, John M Tarbell
Aug 6, 2013·Current Atherosclerosis Reports·Catherine Martel, Gwendalyn J Randolph
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Mar 8, 2003·International Journal of Cardiovascular Interventions·Chao-Wei HwangElazer R Edelman

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