Effect of atorvastatin and diet on non-alcoholic fatty liver disease activity score in hyperlipidemic chickens

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Antonia Martín-CastilloIgnacio Ayala

Abstract

Non-alcoholic steatohepatitis (NASH) is part of the spectrum of non-alcoholic fatty liver disease (NAFLD), which includes from simple steatosis and steatohepatitis, to the most severe cirrhosis and carcinoma, which develops in the absence of excessive alcohol intake. NAFLD is the most common liver disorder in affluent societies. There is no proven treatment for NAFLD/NASH. One of the most frequent adverse effects of statins is an increase in hepatic aminotransferases. Studies that evaluate if the benefits of statins overcome the risks in NASH are lacking. The present study was conceived to explore the effect of both atorvastatin and diet on regression of steatohepatitis, using a chicken experimental model induced by a hyperlipidemic diet (HD). Plasma lipid levels, liver enzymes and hepatic histopathology, as well as image analysis were performed to determine changes in liver lipid deposits and inflammatory infiltration. Features of steatosis, cell-ballooning, and inflammation were scored to obtain the NAFLD activity score (NAS). A severe level of steatosis was found in animals fed on HD. Atorvastatin treated groups showed smaller size of lipid deposits and a lower level of inflammation than non-treated groups. Atorvastatin ther...Continue Reading

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Citations

Apr 14, 2015·Journal of Avian Medicine and Surgery·Hugues BeaufrèreThomas N Tully
Jun 18, 2014·Biochemical and Biophysical Research Communications·Qiuxian PengHongbing Cai
Oct 3, 2018·Journal of Medicinal Food·Yoon Hee ChungJi Hoon Jeong
Nov 29, 2011·International Journal of Experimental Pathology·Viviane Trak-SmayraBernard Fromenty
May 30, 2021·Environmental Science and Pollution Research International·Samar Saber IbrahimMohamed Aboubakr

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