Effect of atrial fibrillation on atrial refractoriness in humans

Circulation
E G DaoudFred Morady

Abstract

The acute effect of atrial fibrillation (AF) on the atrial effective refractory period (ERP) in humans is unknown. In 20 patients without structural heart disease, the atrial ERP was measured before and after pacing-induced AF at drive cycle lengths of 350 and 500 ms. Immediately after spontaneous AF conversion, the post-AF ERP was measured. The pre-AF ERPs at 350 and 500 ms were 206 +/- 23 and 216 +/- 17 ms, respectively. The time to spontaneous conversion of AF was 7.3 +/- 1.9 minutes. The first post-AF ERPs at drive cycle lengths of 350 and 500 ms were 175 +/- 30 ms (P < .0001 versus pre-AF) and 191 +/- 30 ms (P < .0001 versus pre-AF), respectively. The post-AF ERP returned to the pre-AF ERP value after a mean of 8.4 +/- 0.3 minutes. In 15 patients, during the determination of the post-AF ERP, secondary episodes of AF lasting 1 +/- 1.5 minutes were reinduced 6 +/- 3 times per patient. There was a significant inverse logarithmic relationship between the time to reinduction of AF and the duration of secondary episodes of AF (P < .0001, r = 5). In humans, several minutes of induced AF is sufficient to shorten the ERP for up to approximately 8 minutes. The temporal recovery of the ERP is reflected in progressively shorter episod...Continue Reading

References

Sep 1, 1991·Pacing and Clinical Electrophysiology : PACE·A H KadishF Morady
Dec 1, 1988·Pacing and Clinical Electrophysiology : PACE·F MoradyS Schmaltz
Oct 1, 1988·Journal of the American College of Cardiology·E M AntmanP L Friedman
Sep 10, 1987·The New England Journal of Medicine·S L KopeckyR L Frye
Jan 1, 1986·The American Journal of Cardiology·R L GoldJ S Alpert
Nov 1, 1969·The Journal of Clinical Investigation·A D Jose, R R Taylor
Jan 1, 1995·Journal of Electrocardiology·R GoyalF Morady

❮ Previous
Next ❯

Citations

Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert G TielemanHarry J G M Crijns
Jun 5, 2003·The American Journal of Cardiology·Jeff S Healey, Stuart J Connolly
Feb 2, 2000·The Annals of Thoracic Surgery·C W Hogue, M L Hyder
Aug 6, 2000·Current Problems in Cardiology·J SraM Akhtar
Feb 1, 2003·International Journal of Cardiology·Fumio KurogouchiKendo Kiyosawa
May 3, 2003·International Journal of Cardiology·Andrew R J MitchellNeil Sulke
Dec 9, 2003·International Journal of Cardiology·Ijaz A Khan
May 12, 2000·Journal of the American College of Cardiology·M M Scheinman
Sep 15, 2000·Journal of the American College of Cardiology·H J SihJ E Olgin
Jul 10, 2002·Journal of the American College of Cardiology·David SchwartzmanEduardo N Warman
Dec 31, 2002·Journal of the American College of Cardiology·Hung-Fat Tse, Chu-Pak Lau
Sep 4, 1998·Journal of Cardiovascular Electrophysiology·B SchumacherB Lüderitz
Feb 11, 1999·Journal of the American College of Cardiology·P B SparksJ M Kalman
Aug 15, 2008·Journal of Human Hypertension·S Del ColleF Veglio
Feb 18, 2003·Journal of Internal Medicine·J RymanM Rosenqvist
Aug 14, 2003·Pacing and Clinical Electrophysiology : PACE·Bradley P Knight
Mar 11, 2003·Journal of Cardiovascular Electrophysiology·Patrick AttuelSao Seing
Mar 14, 2003·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·S LévyUNKNOWN Working Group on Arrhythmias, Working Group on Cardiac Pacing of the European Society of Cardiology, North American Society
Feb 7, 2013·European Heart Journal·Ziad HijaziLars Wallentin
Sep 30, 2010·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·A John CammUNKNOWN ESC Committee for Practice Guidelines
Sep 4, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Coralie BlancheMarc Zimmermann
Nov 1, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Michael R FranzSanjiv M Narayan
Nov 6, 2002·The American Journal of Geriatric Cardiology·Irina Savelieva, A John Camm
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·H F Tse, C P Lau
Feb 17, 1999·Pacing and Clinical Electrophysiology : PACE·G BorianiB Magnani
Feb 24, 2001·Pacing and Clinical Electrophysiology : PACE·S H LeeS A Chen
Mar 10, 2000·Pacing and Clinical Electrophysiology : PACE·B Brembilla-PerrotP Louis
Jul 29, 2000·Pacing and Clinical Electrophysiology : PACE·D M GilliganK A Ellenbogen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.