PMID: 9437707Jan 1, 1997Paper

Effect of atrial natriuretic peptide on sodium-glucose cotransport in the rat small intestine

Peptides
L V Gonzalez BoscN A Vidal

Abstract

Atrial natriuretic peptide (ANP) decreases sodium absorption in small intestine of rats in vitro under sodium concentration-gradient conditions (SCG) and this effect may be mediated by the inhibition of the sodium/glucose cotransporter (SGLT). In order to assess this hypothesis, the effects of ANP, phloridzine (Phlz) and methylene blue (MB), added alone or together, using a voltage clamp technique in Ussing's chamber with SCG were studied. ANP and Phlz significantly decreased potential difference and short circuit current. Effects of Phlz and ANP were not additive. The addition of MB alone did not affect ion transport, whereas it abolished ANP effects. These data suggest that ANP blocks the SGLT through mechanisms mediated by cGMP and/or NO.

References

Jul 1, 1979·The American Journal of Physiology·G A Kimmich, J Randles
Jan 1, 1988·Reviews of Physiology, Biochemistry and Pharmacology·J Genest, M Cantin
Mar 1, 1986·Canadian Journal of Physiology and Pharmacology·A Martïnez SeeberA L Karara
Nov 1, 1981·The American Journal of Physiology·G A Kimmich, J Randles
Feb 15, 1995·European Journal of Pharmacology·J G Elferink, B M De Koster
May 1, 1993·Scandinavian Journal of Clinical and Laboratory Investigation·G Christensen
Jan 1, 1996·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·F TrischittaT Schettino

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Citations

Jan 26, 1999·Medicinal Research Reviews·J I Kourie, M J Rive
Aug 26, 2000·Peptides·L V González BoscN A Vidal
Jan 12, 2002·Peptides·L V González BoscN A Vidal

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