Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT: A Multicenter Study Using a 3-Dimensional Brain Phantom

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Jarmo TeuhoHidehiro Iida

Abstract

A spatial bias in brain PET/MR exists compared with PET/CT, because of MR-based attenuation correction. We performed an evaluation among 4 institutions, 3 PET/MR systems, and 4 PET/CT systems using an anthropomorphic brain phantom, hypothesizing that the spatial bias would be minimized with CT-based attenuation correction (CTAC). The evaluation protocol was similar to the quantification of changes in neurologic PET studies. Regional analysis was conducted on 8 anatomic volumes of interest (VOIs) in gray matter on count-normalized, resolution-matched, coregistered data. On PET/MR systems, CTAC was applied as the reference method for attenuation correction. With CTAC, visual and quantitative differences between PET/MR and PET/CT systems were minimized. Intersystem variation between institutions was +3.42% to -3.29% in all VOIs for PET/CT and +2.15% to -4.50% in all VOIs for PET/MR. PET/MR systems differed by +2.34% to -2.21%, +2.04% to -2.08%, and -1.77% to -5.37% when compared with a PET/CT system at each institution, and these differences were not significant (P ≥ 0.05). Visual and quantitative differences between PET/MR and PET/CT systems can be minimized by an accurate and standardized method of attenuation correction. If a m...Continue Reading

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Citations

Jul 13, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yi SuMarcus E Raichle
Apr 7, 2017·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·David GrosharLiran Domachevsky
Apr 30, 2017·European Journal of Nuclear Medicine and Molecular Imaging·C M DerooseP Bourguet
Aug 7, 2020·EJNMMI Physics·Johanna HarriesBernhard Sattler
Mar 25, 2017·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Jarmo TeuhoMika Teräs
Aug 27, 2021·EJNMMI Physics·Eve LennieSteven Sourbron
Aug 19, 2021·Medical Physics·Maria Francesca SpadeaJoao Seco

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