Effect of Au-dextran NPs as anti-tumor agent against EAC and solid tumor in mice by biochemical evaluations and histopathological investigations

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Dalia MedhatZakaria El-Khayat

Abstract

Dextran-capped gold nanoparticles (Au-dextran NPs) were prepared exploiting the natural polysaccharide polymer as both reducing and stabilizing agent in the synthesis process, aiming at studying their antitumor effect on solid carcinoma and EAC-bearing mice. To this end, Au-dextran NPs were designed via simple eco-friendly chemical reaction and they were characterized revealing the monodispersed particles with narrow distributed size of around 49nm with high negative charge. In vivo experiments were performed on mice. Biochemical analysis of liver and kidney functions and oxidation stress ratio in addition to histopathological investigations of such tumor tissues were done demonstrating the potentiality of Au-dextran NPs as antitumor agent. The obtained results revealed that EAC and solid tumors caused significant increase in liver and kidney functions, liver oxidant parameters, alpha feto protein levels and diminished liver antioxidant accompanied by positive expression of tumor protein p53 of liver while the treatment with Au-dextran NPs for both types caused improvement in liver and kidney functions, increased liver antioxidant, increased the expression level of B-cell lymphoma 2 gene and subsequently suppressed the apoptoti...Continue Reading

Citations

Jan 10, 2020·Environmental Science and Pollution Research International·Ehab ToussonThulfiqar Fawwaz Mutar
Apr 22, 2020·Biomaterials Science·Mohamed F AttiaFrank Alexis
Dec 5, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ema BurlacuLavinia Berta
Sep 24, 2019·Colloids and Surfaces. B, Biointerfaces·Samah M El-SayedMona El-Banna
Jan 9, 2021·Environmental Science and Pollution Research International·Mabrouk Attia Abd EldaimAbdullah A S Ahmed
May 21, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Mabrouk Attia Abd EldaimHebatalla Nashaat Elsharkawy

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