Abstract
Aurea Helianthus (AH), also known as wild confederate rose or golden sunflower, is a curative herb. It has been used as a medicinal material in China due to its anti-inflammatory, immune regulatory, and anti-oxidant activities. However, its melanogenic effect on skin has not been sufficiently investigated. In this study, we tested whether AH has melanogenic inhibitory activities for the development of effective skin whitening agent. The extract showed inhibition of melanin synthesis and reduced the oxidation of 3, 4-dihydroxyphenilalanine (DOPA) to o-dopaquinone. Additionally, AH downregulated the levels of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase related proteins (TRPs), suggesting that AH has inhibitory effects on melanogenesis. Analysis of the components of AH showed that it contained paprazine and trans-N-feruloyltyramine (FA). We confirmed that the effect of AH resulted from paprazine and FA. Therefore, AH might have potential as an effective candidate for skin whitening.
References
Aug 1, 1977·Experimental Cell Research·R Halaban, A B Lerner
Nov 1, 1992·Pigment Cell Research·Y TomitaH Tagami
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·Z Abdel-MalekV J Hearing
Mar 4, 1996·FEBS Letters·V del Marmol, F Beermann
Jun 1, 1997·Pigment Cell Research·H Z HillD L Mitchell
Jan 7, 2000·Experimental Cell Research·M SeibergS S Shapiro
Jun 7, 2000·Pigment Cell Research·R Buscà, R Ballotti
Jul 8, 2000·The Journal of Investigative Dermatology·T J HornyakE B Ziff
Oct 6, 2007·Biological & Pharmaceutical Bulletin·Mai EfdiHideharu Ishihara
Mar 10, 2009·Bioscience, Biotechnology, and Biochemistry·Jong-Hyuk SungSoon-Sun Hong
Jan 8, 2010·The Journal of Biological Chemistry·Barbara BelleiMauro Picardo
May 17, 2011·Expert Review of Dermatology·Taisuke Kondo, Vincent J Hearing
May 18, 2011·Phytotherapy Research : PTR·Cai-Xia TuYun-Ying Zhang
Nov 19, 2011·The Journal of Investigative Dermatology·Vincent J Hearing
Dec 12, 2013·BMC Complementary and Alternative Medicine·Horng-Huey KoFeng-Lin Yen
Jun 3, 2014·BMC Complementary and Alternative Medicine·Adila TuerxuntayiHaji Akber Aisa
Oct 18, 2014·Nutrition Research and Practice·Kyong-Suk JinByung Woo Kim
Apr 7, 2015·Chemico-biological Interactions·Yunyao JiangMyeong-Hyeon Wang
Jul 15, 2015·Rheumatology·Sian Yik LimHyon K Choi
Jul 20, 2016·International Journal of Molecular Sciences·Stacey A N D'MelloMarjan E Askarian-Amiri
Citations
Nov 23, 2019·Bioscience, Biotechnology, and Biochemistry·Satoshi SuzukiKen-Ichi Kimura
Jun 10, 2020·Scientific Reports·Yoonjin ParkSeungGwan Lee
Feb 10, 2021·Antioxidants·Geum Jin KimHyukjae Choi
Nov 19, 2020·Critical Reviews in Food Science and Nutrition·William LeonardZhongxiang Fang
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marwa RoumaniRomain Larbat
Jul 25, 2021·International Journal of Molecular Sciences·Hye Yeon LimJae Youl Cho
May 19, 2020·Journal of Agricultural and Food Chemistry·Weixin WangShengmin Sang