Effect of Aurea Helianthus stem extract on anti-melanogenesis

Bioscience, Biotechnology, and Biochemistry
Yehyang KimSong Seok Shin

Abstract

Aurea Helianthus (AH), also known as wild confederate rose or golden sunflower, is a curative herb. It has been used as a medicinal material in China due to its anti-inflammatory, immune regulatory, and anti-oxidant activities. However, its melanogenic effect on skin has not been sufficiently investigated. In this study, we tested whether AH has melanogenic inhibitory activities for the development of effective skin whitening agent. The extract showed inhibition of melanin synthesis and reduced the oxidation of 3, 4-dihydroxyphenilalanine (DOPA) to o-dopaquinone. Additionally, AH downregulated the levels of microphthalmia-associated transcription factor (MITF), tyrosinase and tyrosinase related proteins (TRPs), suggesting that AH has inhibitory effects on melanogenesis. Analysis of the components of AH showed that it contained paprazine and trans-N-feruloyltyramine (FA). We confirmed that the effect of AH resulted from paprazine and FA. Therefore, AH might have potential as an effective candidate for skin whitening.

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Citations

Nov 23, 2019·Bioscience, Biotechnology, and Biochemistry·Satoshi SuzukiKen-Ichi Kimura
Nov 7, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marwa RoumaniRomain Larbat
Jul 25, 2021·International Journal of Molecular Sciences·Hye Yeon LimJae Youl Cho
May 19, 2020·Journal of Agricultural and Food Chemistry·Weixin WangShengmin Sang

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Methods Mentioned

BETA
ELISA
Protein Assay
Assay
NMR

Software Mentioned

CSAnalyzer4

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