PMID: 6103442May 24, 1980Paper

Effect of azelaic acid on human malignant melanoma

Lancet
M Nazzaro-PorroG Morpurgo

Abstract

In 23 patients with malignant melanoma, including some with metastases and terminal patients, topical and oral (10--15 g daily) azelaic acid given for 1--12 weeks before surgical excision of the lesions was followed by arrest and subsequent regression of the advancing edge of lesions, reduction in size and flattening of nodular areas, and progressive lightening of pigmentation. Histological and ultrastructural effects included: degeneration and disappearance of malignant epidermal and dermal melanocytes with reduction of junctional activity; epidermal proliferation and return towards normal organisation; reappearance of papillary dermis, pilosebaceous units, and sweat glands; separation of dermal melanoma tumour masses into smaller collections of cells by regenerating connective tissue; and increase in number of dermal mast cells, macrophages, and round cells. These preliminary results indicate a direct cytotoxic effect of azelaic acid on melanocytes of human melanoma.

References

Dec 1, 1979·The British Journal of Dermatology·A S BreathnachG Morpurgo

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Citations

Mar 13, 2013·American Journal of Clinical Dermatology·Elizabeth A Quigley, Allan C Halpern
Dec 1, 1995·Journal of the American Academy of Dermatology·L M Cohen
Dec 1, 1987·Journal of the American Academy of Dermatology·M Nazzaro-Porro
Jan 1, 1984·Experimental Pathology·G MingroneM Nazzro-Porro
Jan 1, 1983·The British Journal of Ophthalmology·H E Willshaw, K Rubinstein
Jun 10, 2005·American Journal of Clinical Dermatology·Olivia Stevenson, Imtiaz Ahmed
May 3, 2007·International Journal of Dermatology·Aditya K Gupta, Melissa D Gover
Nov 9, 2014·Expert Opinion on Pharmacotherapy·Sarah SlootJonathan S Zager
Jul 15, 2015·Critical Reviews in Food Science and Nutrition·Ville Mikael Koistinen, Kati Hanhineva
Jul 1, 1984·The British Journal of Dermatology·A S BreathnachS Passi
Jun 1, 1986·The British Journal of Dermatology·D I McLean, K K Peter
Jan 1, 1986·The British Journal of Dermatology·F HuD J Teramura
Apr 1, 1983·Medical Hypotheses·D M Rubin, E J Rubin
May 1, 1989·JPEN. Journal of Parenteral and Enteral Nutrition·G MingroneE Castagneto
Dec 17, 2008·Dermatologic Therapy·Gert J SmalbergerAmor Khachemoune
Jan 1, 1991·Free Radical Research Communications·S PassiM Nazzaro-Porro
Jul 1, 1983·The British Journal of Dermatology·M Nazzaro-PorroG Zina
Apr 1, 1987·The British Journal of Dermatology
Jan 1, 1984·Biochemical Pharmacology·S PassiG Serlupi-Crescenzi
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Nov 1, 1985·The Journal of Investigative Dermatology·H LeiblK Wolff
May 28, 2021·Current Drug Research Reviews·Supriya Kumari SinghDeepinder Singh Malik

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