Effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis

Journal of Periodontal Research
Gülnur EmingilTimo Sorsa

Abstract

Emingil G, Han B, Özdemir G, Tervahartiala T, Vural C, Atilla G, Baylas H, Sorsa T. The effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. J Periodont Res 2012; 47: 729-739. © 2012 John Wiley & Sons A/S Background and Objective:  To study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parameters, and on the MMP-8 and TIMP-1 levels in gingival crevicular fluid, over a 6-mo time-period in patients with generalized aggressive periodontitis. Thirty-two patients with generalized aggressive periodontitis were included in this randomized, double-blind, placebo-controlled, parallel-arm study. They were randomly assigned to azithromycin or placebo groups (500 mg once daily for 3 d). Probing depth, clinical attachment levels, presence of bleeding on probing and plaque were recorded. Gingival crevicular fluid samples were obtained from one single-rooted tooth, while microbiological samples were obtained from two single-rooted teeth, all with a probing depth of ≥ 6 mm. Microbiological parameters were analyzed by quantitative real-time ...Continue Reading

Associated Clinical Trials

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Citations

Mar 30, 2013·Journal of Periodontology·Patricia Furtado GonçalvesLuciana Macchion Shaddox
May 11, 2013·Journal of Periodontology·Georgios N Belibasakis, Thomas Thurnheer
Apr 23, 2014·Photodiagnosis and Photodynamic Therapy·Jing QiaoHuimei Jia
Apr 30, 2016·Indian Journal of Pharmacology·Sajith Abdul LatifPriyanka Jairaj Dalvi
Dec 17, 2014·Periodontology 2000·Magda FeresMarcelo Faveri
Jun 20, 2015·Journal of Clinical Periodontology·Cleverton Correa RabeloLeandro Chambrone
Jan 30, 2020·Journal of Clinical Periodontology·Wim TeughelsDavid Herrera
Nov 17, 2020·The Cochrane Database of Systematic Reviews·Shivi KhattriGiovanni Lodi

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