Abstract
Ingestion of Bacillus subtilis C-3102 spores (C-3102) has relieved the symptoms of diarrhoea in piglets and changed the composition of gut microbiota in humans. Recently, it was suggested that the composition of the human gut microbiota affects stool consistency. In this study, a double-blind, randomised, placebo-controlled trial was conducted to assess the preventive effects of chronic diarrhoea in healthy volunteers with loose stools by ingestion of C-3102. The results showed that oral doses of C-3102 tablets significantly decreased the Bristol Stool Scale score and stool frequency, and also significantly improved abdominal sounds. With regard to gut microbiota, the relative abundance of Lachnospira, Actinomyces and SMB53 were significantly changed. This study shows that C-3102 could be effective for treating loose stools (Trial registration: UMIN000022583, http://tinyurl.com/ya4refqn ).
References
Feb 17, 1990·BMJ : British Medical Journal·L J O'DonnellK W Heaton
Dec 5, 2003·Journal of Hypertension·Xavier Jeunemaitre
Feb 22, 2007·The Journal of Nutrition·Michael de Vrese, Philippe R Marteau
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
Feb 22, 2011·Tropical Medicine & International Health : TM & IH·Phalguni DuttaMrinal Kanti Chatterjee
Sep 13, 2012·Beneficial Microbes·M HatanakaN Yamamoto
Feb 28, 2013·Beneficial Microbes·M Ratna SudhaM Asin Kumar
Sep 1, 1989·Journal of Chemical Ecology·W R LusbyR R Heath
Oct 29, 2014·Intestinal research·Jun HeoByung Ik Jang
Feb 24, 2015·Scientific Reports·Jiro NakayamaYuan-Kun Lee
Mar 18, 2015·World Journal of Gastroenterology : WJG·Tina DidariMohammad Abdollahi
Jun 13, 2015·Gut·Doris VandeputteJeroen Raes
Oct 23, 2015·The Journal of Nutrition·Chang HuangXi Ma
Feb 29, 2016·Nutrition Journal·Muhammed MajeedSuresh Kumar Karri
Apr 30, 2016·Science·Gwen FalonyJeroen Raes
Jan 8, 2017·Gut·Doris VandeputteJeroen Raes
Feb 10, 2017·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Hai-Ning LiuTao-Tao Liu
Mar 6, 2017·Molecular Medicine Reports·Yilong YangWei Chen
Citations
Jan 15, 2019·Beneficial Microbes·M Ratna SudhaA K Verma
Jul 2, 2019·Journal of Gastroenterology and Hepatology·Byong Duk YeKyuyoung Song
Jun 20, 2020·Nursing Research·Stephanie D SealschottMichael T Bailey
Aug 14, 2019·Nutrients·Kensei NishidaKazuhito Rokutan
Mar 20, 2019·Current Gastroenterology Reports·Maya FayfmanShanthi Srinivasan
Nov 30, 2019·Journal of Toxicology·B Appala NaiduZachary D Abbott
May 7, 2020·Scientific Reports·Misaki HatanakaTeppei Nakamura
Dec 3, 2020·Nutrients·Reiko TanihiroYasunori Nakamura
Dec 28, 2019·Toxicology Reports·Misaki HatanakaTsuyoshi Takara
Apr 10, 2021·Frontiers in Cellular and Infection Microbiology·Dan LuoHui Peng
May 1, 2021·The Journal of Poultry Science·Toki NishiyamaNaoyuki Yamamoto