PMID: 3527702Jun 1, 1986

Effect of Bacteroides fragilis grown in the presence of clindamycin, metronidazole and fusidic acid on opsonization and killing of Escherichia coli

European Journal of Clinical Microbiology
F NamavarD M MacLaren

Abstract

Bactericidal action of human polymorphonuclear leucocytes on Escherichia coli in the presence of Bacteroides fragilis grown in subinhibitory concentrations of clindamycin, metronidazole and fusidic acid was studied. Bacteroides fragilis grown in the absence of drugs significantly inhibited the killing of Escherichia coli. Bacteroides fragilis grown in the presence of the drugs had a reduced inhibitory effect on the killing of Escherichia coli but this reduction was only significant for Bacteroides fragilis grown in 1/2 MIC of clindamycin. The phagocytosis of Bacteroides fragilis grown with and without clindamycin, as measured by killing, was the same. Complement consumption of Bacteroides fragilis grown with and without clindamycin did not differ. Clindamycin-treated Bacteroides fragilis fixed C3 to a significantly lower degree than did untreated bacteria. The chemiluminescence of Escherichia coli opsonized with serum preincubated with clindamycin-treated Bacteroides fragilis was significantly higher than with serum preincubated with untreated bacteria. These results suggested that in killing experiments of mixed Escherichia coli and Bacteroides fragilis, the mechanism underlying the reduced inhibitory capacity of clindamycin-e...Continue Reading

References

Dec 17, 1977·Lancet·H R InghamA A Codd
Jun 1, 1977·Journal of Clinical Pathology·D TharagonnetJ B Selkon
Mar 1, 1979·The Journal of Antimicrobial Chemotherapy·A B OnderdonkJ G Bartlett
Jun 1, 1985·Journal of Medical Microbiology·A M Verweij-Van VughtD M MacLaren
Aug 1, 1982·Journal of Medical Microbiology·G R Jones, C G Gemmell
Oct 1, 1983·European Journal of Clinical Microbiology·D Milatovic
Oct 1, 1983·The Journal of Antimicrobial Chemotherapy·N M BoeB H Minshew
Jan 1, 1984·Antonie van Leeuwenhoek·D M MacLarenJ A Kaan
Sep 1, 1983·Antimicrobial Agents and Chemotherapy·D MilatovicJ Verhoef
Mar 1, 1984·The Journal of Infectious Diseases·T H Steinberg, W L Hand
Nov 1, 1981·Journal of Medical Microbiology·H R InghamJ B Selkon
Mar 1, 1982·Antimicrobial Agents and Chemotherapy·R C Prokesch, W L Hand

Related Concepts

Antibiotics
Bacteroides fragilis
Dalacin C
Hemolytic Complement
Complement Fixation Tests
Complement C3 precursor
Alkalescens-Dispar Group
Fusidin
Phosphorescent Measurements
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