PMID: 6164147Dec 1, 1980Paper

Effect of balanced anesthesia on lung histamine release in patients operated on for mitral heart defects with varying degrees of pulmonary hypertension

Vestnik khirurgii imeni I. I. Grekova
G N Gimmel'farbN I Khan

Abstract

The histamine concentration was estimated in the mixed venous and arterial blood in 28 patients with mitral defects subjected to closed mitral commissurotomy under balanced anesthesia. The oxygen content was determined simultaneously and the amount of blood shunting in the lungs was calculated by the oxygen method. It was established that the amount of histamine in the mixed venous blood coming to lungs was increased in patients with high degree lung hypertension. The balanced anesthesia itself did not influence the histamine concentration in the blood. The cessation of anesthesia, however, is followed by increased histamine concentration in the blood of patients with high lung hypertension. The process of blood shunting in the lungs is not controlled by histamine.

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.