PMID: 379676Jun 1, 1979

Effect of barbiturates on release endogenous amino acids from rat cortex slices

Neurochemical Research
R W Cutler, J Young

Abstract

The potassium-stimulated, calcium-dependent release of endogenous GABA and glutamic acid was suppressed by pentobarbital. The ouabain and veratridine-stimulated fluxes of the amino acids, calcium-independent processes, were not suppressed by pentobarbital. Release of GABA and glutamic acid was not suppressed by pentobarbital in the presence of the calcium ionophore A23187. Of eight barbiturates studied at equimolar concentrations six were found to inhibit GABA release. Thiopental was the most potent, and phenobarbital and secobarbital were inactive.

References

Dec 13, 1988·Brain Research·B D WinegarS W Leslie
Oct 20, 1992·European Journal of Pharmacology·A J PalmerD Lodge
Jan 1, 1980·Progress in Neurobiology·F A Henn, S W Henn
Jan 1, 1982·Progress in Neurobiology·J A Richter, J R Holtman
Sep 1, 1983·Clinical and Experimental Pharmacology & Physiology·J H Skerritt, G A Johnston
Jan 1, 1982·Epilepsia·R L MacDonald, M J McLean
Dec 8, 2011·Neurochemical Research·Donald A GodfreyAllan M Rubin
Jan 15, 2013·Neuromodulation : Journal of the International Neuromodulation Society·Yuhei MatsumuraTakamitsu Yamamoto
Aug 1, 1982·Journal of Neurochemistry·M Willow, F L Bygrave
Jan 1, 1982·British Journal of Pharmacology·T J Kendall, M C Minchin
Nov 19, 1984·FEBS Letters·A PastuszkoM Erecińska

Citations

Dec 6, 1974·Brain Research·R W CutlerD S Dudzinski
Nov 1, 1974·Journal of Neurochemistry·R W Cutler, D S Dudzinski
Jun 15, 1972·Biochemical Pharmacology·R Shankaran, J H Quastel
Apr 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·G Briel, V Neuhoff
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS

Related Concepts

Calcium [EPC]
Secobarbital
Veratridine
Cortex Bone Disorders
Adrenal Cortex Diseases
Diabutal
Calcium
Amino Acids, I.V. solution additive
Potassium
Ouabain

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