Effect of barodenervation on c-Fos expression in the medulla induced by static muscle contraction in cats

The American Journal of Physiology
J LiJ H Mitchell

Abstract

A previous study has shown increased Fos-like immunoreactivity (FLI), a marker of neural activation, in the nucleus of the solitary tract (NTS) and the ventrolateral medulla (VLM) after static muscle contraction elicited by electrical stimulation of L7 and S1 ventral roots of the spinal cord in anesthetized, baroreceptor-intact cats. Because the electrically induced static muscle contraction reflexly increased arterial blood pressure, the concomitant activation of the arterial baroreceptor reflex during static muscle contraction may have resulted in some of the FLI labeling that was observed in the medulla. The purpose of this study was to determine regions in the medulla that are activated by muscle contraction in the absence of arterial baroreceptor input. Electrical stimulation of L7 and S1 ventral roots of the spinal cord was used to elicit static muscle contraction, and FLI in the medulla was determined in barointact and barodenervated cats. In barointact contraction cats, FLI was observed in the lateral reticular nucleus (LRN), NTS, lateral tegmental field (FTL), subretrofacial nucleus (SRF), and A1 region of the medulla. In barodenervated contraction cats, FLI increased in the same regions; however, the number of FLI-lab...Continue Reading

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Citations

Nov 22, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J Li, J H Mitchell
Apr 12, 2001·American Journal of Physiology. Heart and Circulatory Physiology·J Li, J T Potts
Dec 18, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Scott A SmithJianhua Li
Apr 9, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Megan N MurphyScott A Smith
Mar 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Jianhua Li, Jere H Mitchell
Jun 19, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Satoshi KobaJianhua Li
Jun 14, 2000·Journal of Applied Physiology·G M Toney, S W Mifflin
Sep 17, 2011·Journal of Applied Physiology·Chikara AbeHironobu Morita

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