PMID: 44231Dec 1, 1979

Effect of baroreceptor deafferentation on central catecholamines in the rat

Clinical Science
M A PettyJ L Reid

Abstract

1. Sinoaortic deafferentation in the rat leads to increased blood pressure and heart rate. 2. Early increases in tyrosine hydroxylase activity both in brain stem and hypothalamus suggest that increased noradrenaline synthesis may contribute to the development of neurogenic hypertension. 3. After 4 weeks, phenylethanolamine-N-methyltransferase activity was reduced in the hypothalamus. 4. Noradrenaline- and adrenaline, but not dopamine-containing neurones may participate in regulation of sympathetic efferent activity.

Related Concepts

Diastolic Blood Pressure
Neurons
Brain
Catecholamines Measurement
Malignant Neoplasm of Brain Stem
Pressoreceptors
Norepinephrine, (+, -)-Isomer
Epinephrine Measurement
Medihaler-Epi
Norepinephrine

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