Effect of Baseline Characteristics on the Pain Response to Pregabalin in Fibromyalgia Patients with Comorbid Depression

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Stuart L SilvermanAndrew Clair

Abstract

To evaluate the effect of baseline characteristics on the treatment response to pregabalin in fibromyalgia (FM) patients with depression. Post hoc analysis from a randomized, double-blind, placebo-controlled, two-way crossover study of pregabalin (300 or 450 mg/day, twice daily). A total of 193 FM patients taking an antidepressant for comorbid depression. The effect of patient baseline characteristics on the treatment response to pregabalin vs placebo was assessed for the primary efficacy end point (mean pain score on an 11-point numeric rating scale). Variables were analyzed using a linear mixed effects model with sequence, period, and treatment as fixed factors, and subject within sequence and within subject error as random factors. Pregabalin significantly improved mean pain scores vs placebo irrespective of age, duration of FM, number of prior FM medications, depression diagnosis, shorter-term depression (<10 years), prior or no prior opioid use, pain severity, anxiety severity, and sleep disruption severity (all P < 0.05). Compared with placebo, pregabalin did not significantly affect mean pain scores in patients with comorbid insomnia, irritable bowel syndrome, or gastroesophageal reflux disease; severe FM; a diagnosis of...Continue Reading

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Citations

Mar 10, 2018·Current Medical Research and Opinion·Lesley M ArnoldLloyd Knapp
Dec 22, 2020·Therapeutic Advances in Gastroenterology·Sharon ErdrichJoanna E Harnett
Feb 3, 2021·Journal of Cannabis Research·Erinn C Cameron, Samantha L Hemingway
Mar 5, 2021·Journal of Pain Research·Xiao ZhangFengchun Zhang

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