PMID: 7526721Sep 1, 1994Paper

Effect of basic fibroblast growth factor on normal tympanic membrane

American Journal of Otolaryngology
M Mondain, A Ryan

Abstract

Basic fibroblast growth factor (bFGF) is mitogenic for the cell types that constitute the tympanic membrane and has been shown to potentiate tympanic membrane healing. The purpose of this study is to investigate the direct effect of bFGF application on normal tympanic membrane. bFGF was applied to the normal tympanic membrane of 10 guinea pigs via either the external auditory external canal or the middle ear. The drug (400 ng) was delivered on days 0, 1, and 2. The contralateral ear was used as a control. The effects were assessed on day 3. The cumulative area and the average area of blood vessel in each session of TM was greater after bFGF application than placebo. The number of vessels remained unchanged. A proliferation of keratinocytes was observed. These results suggest that bFGF induces a vasodilatation in the tympanic membrane thereby increasing blood supply. This might explain the acceleration of healing of TM perforations after bFGF application.

References

Jan 1, 1989·Progress in Growth Factor Research·M Klagsbrun
Oct 31, 1988·Biochemical and Biophysical Research Communications·P CuevasA Baird
Jul 1, 1988·The Journal of Surgical Research·G S McGeeA A Demetriou
Jan 1, 1968·Acta Oto-laryngologica·D J Lim
Apr 1, 1966·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R C Graham, M J Karnovsky

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Citations

Oct 4, 2012·Tissue Engineering. Part B, Reviews·Bing Mei TehMarcus D Atlas
Oct 15, 2014·The International Journal of Biochemistry & Cell Biology·Tadeusz PawelczykJerzy Kuczkowski
Jul 19, 2018·The Journal of Laryngology and Otology·Z-C LouJ Xiao
Nov 27, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaTadahiko Wada
May 20, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery· Jian-Yang
Feb 13, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Nobuhiro HakubaKiyofumi Gyo
May 26, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shan XuNing Yang

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