Effect of BCG stimulus on proinflammatory cytokine production in laryngeal cancer

Cancer Immunology, Immunotherapy : CII
Luiz Carlos Conti-FreitasNorma Tiraboschi Foss

Abstract

Evaluate the production of TNF and IL-6 in the supernatant of peripheral blood mononuclear cell (PBMC) cultures of patients with supraglottic laryngeal cancer before and after surgical treatment. Adherent cell cultures were stimulated with LPS and BCG. Fourteen patients with advanced supraglottic laryngeal cancer were studied. Cytokine concentration was determined by ELISA in supernatants of mononuclear cell cultures. In non-stimulated cultures, lower TNF cytokine levels were detected during the late postoperative (LP) period compared to control (P = 0.02). LP TNF and IL-6 levels were high in cultures stimulated with LPS compared with the preoperative period (PREOP) (P = 0.007; P = 0.008, respectively). Stimulation with BCG led to increased levels of TNF and IL-6 during the LP period compared to control (P = 0.001; P = 0.04, respectively). BCG is able to modulate the immune response of patients with advanced supraglottic laryngeal cancer in vitro, increasing the secretion of TNF and IL-6 by macrophages during the postoperative period.

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·E A CarswellB Williamson
Sep 1, 1991·Archives of Otolaryngology--head & Neck Surgery·O GalloR Bondi
Feb 1, 1982·Oral Surgery, Oral Medicine, and Oral Pathology·C Scully
Jan 1, 1996·Critical Reviews in Immunology·M H BemelmansW A Buurman
Dec 16, 1998·Immunological Reviews·P MarrackJ Kappler
Feb 11, 1999·The New England Journal of Medicine·C Gabay, I Kushner
Jul 13, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·A DietzH Maier
Jan 5, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·R Kurzrock
Feb 6, 2007·The Laryngoscope·Luiz Carlos Conti-FreitasNorma Tiraboschi Foss
Oct 27, 2007·Asian Journal of Surgery·Azad H A Razack

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Citations

Jan 8, 2013·Journal of Inflammation Research·Erika Muller Ramalho ZenhaNorma Tiraboschi Foss
Feb 9, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yue-Can ZengYu-Ping Xiao
Jun 1, 2021·Frontiers in Oncology·Liese VandeborneGauthier Bouche

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