Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women

Genetics and Molecular Biology
Jéssica de OliveiraLupe Furtado-Alle

Abstract

Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G > A (rs1126680), 1615GA (rs1803274), 1914A < G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI < 25/n = 81). BCHE SNPs genotyping was obtained by TaqMan allelic discrimination assay and by RFLP-PCR. Plasmatic BChE activity was measured using propionylthiocholine as substrate. Similar allele frequencies were found in obese and non-obese women for the three studied SNPs (p > 0.05). The dominant and recessive models were tested, and different effects were found. The -116A allele showed a dominant effect in BChE activity reduction in both non-obese and obese women (p = 0.045 and p < 0.001, respectively). The 1914A > G and 1615GA SNPs influenced the TG levels only in obese women. The 1914G and the 1615A alleles were associated with decrease...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Jan 1, 1991·Human Heredity·E A Chautard-Freire-MaiaM M Vieira
Oct 25, 1990·Nucleic Acids Research·C F BartelsB N La Du
Jun 15, 1989·The Biochemical Journal·A Chatonnet, O Lockridge
Oct 22, 2002·Scandinavian Journal of Clinical and Laboratory Investigation·V M AlcântaraG Picheth
Jun 29, 2004·Life Sciences·János KálmánZoltán Janka
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Dec 16, 2004·Transplantation·Minoru IwasakiKoichi Tanaka
Mar 22, 2005·Atherosclerosis·Vincent BatailleJean Ferrières
Apr 22, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Vânia M AlcântaraEleidi A Chautard-Freire-Maia
May 24, 2005·Clinical Biochemistry·Edward W RandellGuang Sun
May 3, 2008·Chemico-biological Interactions·Bin LiOksana Lockridge
Jun 14, 2008·Chemico-biological Interactions·Lupe Furtado-AlleEleidi A Chautard-Freire-Maia
Jun 1, 1947·The American Journal of Physiology·W C WESCOE, C C HUNT
Apr 9, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Renato ScacchiRosa Maria Corbo
Apr 16, 2011·The Journal of Pharmacology and Experimental Therapeutics·Anne M VallePalmer Taylor
Sep 25, 2012·Chemico-biological Interactions·Thaís Jannuzzi ChavesLupe Furtado-Alle
Dec 29, 2012·Genetics and Molecular Biology·Isabela M W SilvaLupe Furtado-Alle
Nov 16, 2013·Arquivos brasileiros de endocrinologia e metabologia·Gerusa Eisfeld MilanoLupe Furtado Alle
Sep 25, 2014·Genetics and Molecular Biology·Luciane Viater TurekLupe Furtado Alle
Feb 13, 2015·Nature·Adam E LockeElizabeth K Speliotes

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Citations

Feb 2, 2019·Journal of Molecular Neuroscience : MN·Sadaf MunirSyed M Nurulain
Aug 21, 2021·Biochemical Genetics·Sliha AwanSyed M Nurulain

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Methods Mentioned

BETA
genotyping
electrophoresis

Software Mentioned

Haploview

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