Effect of behavioral testing on spine density of basal dendrites in the CA1 region of the hippocampus modulated by (56)Fe irradiation

Behavioural Brain Research
Jacob RaberJohn R Fike

Abstract

A unique feature of the space radiation environment is the presence of high-energy charged particles, including (56)Fe ions, which can present a significant hazard to space flight crews during and following a mission. (56)Fe irradiation-induced cognitive changes often involve alterations in hippocampal function. These alterations might involve changes in spine morphology and density. In addition to irradiation, performing a cognitive task can also affect spine morphology. Therefore, it is often hard to determine whether changes in spine morphology and density are due to an environmental challenge or group differences in performance on cognitive tests. In this study, we tested the hypothesis that the ability of exploratory behavior to increase specific measures of hippocampal spine morphology and density is affected by (56)Fe irradiation. In sham-irradiated mice, exploratory behavior increased basal spine density in the CA1 region of the hippocampus and the enclosed blade of the dentate gyrus. These effects were not seen in irradiated mice. In addition, following exploratory behavior, there was a trend toward a decrease in the percent stubby spines on apical dendrites in the CA3 region of the hippocampus in (56)Fe-irradiated, bu...Continue Reading

References

Apr 1, 1970·The American Journal of Anatomy·A Peters, I R Kaiserman-Abramof
Jan 1, 1993·Annual Review of Physiology·C H Bailey, E R Kandel
Jan 1, 1989·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·S B Curtis, J R Letaw
Jan 7, 2004·Nature Reviews. Neuroscience·Raphael Lamprecht, Joseph LeDoux
May 6, 2004·Molecular Neurobiology·Benedetta Leuner, Tracey J Shors
Sep 25, 2004·Hippocampus·J A MarkhamJ M Juraska
Apr 2, 2005·Nature Reviews. Neuroscience·Menahem Segal
Feb 1, 2006·Journal of Neuroscience Research·O von Bohlen und HalbachK Unsicker
Jun 3, 2006·Journal of Applied Physiology·S A HamiltonT A Bateman
Feb 26, 2009·Cerebral Cortex·Takuma KitanishiMaki K Yamada
Apr 16, 2010·Journal of Neurophysiology·Michael J EckertWickliffe C Abraham
Apr 16, 2011·Development, Growth & Differentiation·Kazuo Emoto
May 10, 2011·International Journal of Radiation Oncology, Biology, Physics·Laura E VillasanaJacob Raber
Mar 10, 2012·International Journal of Radiation Oncology, Biology, Physics·Gwendolen E HaleyJacob Raber
Apr 3, 2012·Molecular and Cellular Neurosciences·Vaishali A Kulkarni, Bonnie L Firestein
Apr 24, 2012·Neuroscience·B Leuner, T J Shors

❮ Previous
Next ❯

Citations

Oct 11, 2016·Scientific Reports·Vipan K PariharCharles L Limoli
Sep 11, 2018·The Journal of Comparative Neurology·Dara L DicksteinCharles L Limoli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.