Effect of benzo[a]pyrene on the expression of miR-126, miR-190a and their target genes EGFL7, TP53INP1 and PHLPP1 in primary endometrial cells

Journal of Biochemical and Molecular Toxicology
M D ChanyshevL F Gulyaeva

Abstract

The main topic of this study was to investigate the effect of benzo[a]pyrene (BP) on microRNAs and their target genes expression levels in primary cell cultures from normal and malignant endometrial tissue. MicroRNA-126 (miR-126) and miR-190a were most sensitive to BP treatment. The treatment of both cultures with BP was accompanied by a decrease of miR-126 level and an increase of EGFL7 gene expression level. BP-induced upregulation of miR-190a was detected only in normal cells and it was accompanied with decrease of mRNA levels of TP53INP1 and PHLPP1 genes. Taking into account that BP promoted the proliferation of normal cells and amplified apoptosis of cancer cells, it is possible that miR-190a is involved in general cellular response to BP. The findings of this study indicate that miR-190a and its target genes may be involved in the regulation of cell fate under BP treatment.

References

Jun 1, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·G D CharlesE W Carney
Aug 21, 2001·Molecular Cell·S OkamuraY Nakamura
Jun 24, 2005·The American Journal of Pathology·Luisa CampagnoloHeidi Stuhlmann
Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Oct 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fan WuChun Fan
Nov 26, 2009·Translational Research : the Journal of Laboratory and Clinical Medicine·Geoffrey S Ginsburg, Huntington F Willard
Nov 3, 2010·Current Genomics·Rachel E EllsworthDarrell L Ellsworth
Jul 5, 2011·Annual Review of Genomics and Human Genetics·Isaac S Chan, Geoffrey S Ginsburg
Oct 4, 2011·Cell·Herbert W Virgin, John A Todd
Nov 1, 2011·Cancer Research·Suzanne DelfortrieFabrice Soncin
Oct 26, 2013·Toxicology·Costas KoufarisNigel J Gooderham
Sep 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Ayla Valinezhad Orang, Abolfazl Barzegari
Jul 8, 2015·Journal of Cancer Research and Therapeutics·Olga A KovalVladimir A Richter
Jul 5, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Soo-Min KimKyung-Chul Choi
Jul 1, 2013·Personalized Medicine·Ruth Chadwick, Alan O'Connor

❮ Previous
Next ❯

Citations

Oct 19, 2019·Cancer Cell International·Yue Yu, Xu-Chen Cao
Aug 18, 2021·Environmental Science and Pollution Research International·Rupa RaniRajesh Ahirwar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.