PMID: 9175020Jan 1, 1997Paper

Effect of beta 2glycoprotein I and human monoclonal anticardiolipin antibody on the protein S/C4b-binding protein system

Lupus
T AtsumiG R Hughes

Abstract

The effect of beta 2glycoprotein I (beta 2GPI) and human monoclonal anticardiolipin antibody (aCL) on the protein S/C4b-binding protein (C4BP) system was evaluated. The binding of C4BP to protein S was assessed by ELISA in the presence of beta 2GPI with/without human monoclonal aCL. beta 2GPI downregulated the binding between S and C4BP significantly. Human monoclonal aCL abolished the beta 2GPI inhibitory effect in a calcium (Ca++) independent fashion. In separate experiments, the reactivity of aCL towards protein S in the presence or absence of beta 2GPI and cardiolipin was investigated. Monoclonal aCL bound to protein S only in the presence of a combination of beta 2GPI and cardiolipin. This binding was Ca++ dependent. These findings suggest that human monoclonal aCL increases the affinity of C4BP for protein S, and that protein S may represent one of the targets for aCL when combined with beta 2GPI and cardiolipin. Both issues may explain acquired free protein S deficiency and the attendant risk of thrombosis in patients with aCL.

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Citations

Jul 27, 2001·Current Rheumatology Reports·J T Merrill
Aug 15, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Chris GardinerIan J Mackie
Apr 10, 2015·Helicobacter·Serdar Umit SarıcıOkan Ozcan
Jul 20, 2010·Journal of Autoimmunity·Panayiotis G Vlachoyiannopoulos, John G Routsias
Oct 28, 2004·Thrombosis Research·E Nigel Harris, Silvia S Pierangeli
Feb 3, 2005·International Immunopharmacology·Enrico Maria ZardiAntonella Afeltra
Sep 6, 2001·Rheumatic Diseases Clinics of North America·J T Merrill
Feb 24, 2006·Blood·Gabriela Cesarman-MausKatherine A Hajjar
Jan 8, 2021·Thrombosis and Haemostasis·Giorgia GrossoElisabet Svenungsson

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