PMID: 16943Jun 1, 1977

Effect of beta adrenergic agonist, prostaglandins, and cortisol on lymphocyte levels of cyclic adenosine monophosphate and glycogen: abnormal lymphocytic metabolism in asthma

The Journal of Allergy and Clinical Immunology
T P LeeC E Reed

Abstract

Decreased beta adrenergic regulation of cyclic adenosine monophosphate (cAMP) in lymphocytes has been described in asthma. We investigated adrenergic stimulation of glycogenolysis and responses to prostaglandin E1 (PGE1). Lymphocytes from 24 normal and 24 mild asthmatic subjects who had no drugs for at least 2 weeks were separated on Ficoll-hypaque and incubated in medium 199 with Hepes buffer. Beta adrenergic stimulation of cAMP and glycogenolysis was reduced in the asthmatics (p less than 0.05). PGE produced less of a rise in cAMP in asthmatics than in normals, but the difference was not significant (p greater than 0.05) and glycogenolysis was normal. Cortisol added in vitro potentiates the effect of isoproterenol and PGE1--but in the presence of cortisol the response of the asthmatic cells to isoproterenol is still lower than that of normal cells. This observation would support that "beta adrenergic blockade" is the major defect of asthmatic cells. The conclusion is further supported by the observation that the degree of the blockade is associated with a pathologic condition.

References

Jan 1, 1988·European Journal of Clinical Pharmacology·T SandströmL Rosenhall
May 15, 1990·Mechanisms of Ageing and Development·P B Davis, P J Byard
Nov 1, 1990·British Journal of Clinical Pharmacology·P HjemdahlA Eklund
Mar 1, 1997·Respirology : Official Journal of the Asian Pacific Society of Respirology·Y KawakamiK Furuya
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·P MillsM Ziegler
Sep 1, 1985·Acta Pharmacologica Et Toxicologica·G SagerS Jacobsen
Feb 1, 1985·Acta Pharmacologica Et Toxicologica·F Lanefelt, A Martinsson

Citations

Jul 1, 1972·The Journal of Allergy and Clinical Immunology·P J LogsdonR G Coffey
Jan 1, 1974·The Journal of Allergy and Clinical Immunology·E GillespieL M Lichtenstein
Apr 1, 1973·The Journal of Allergy and Clinical Immunology·H S Nelson
Nov 1, 1968·The Journal of Allergy·E Middleton, S R Finke

Related Concepts

Metabolic Process, Cellular
Phenylephrine Hydrochloride
Z-Max
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Ficoll
Lymphoid Cells
Cyclic AMP
Thyroid Hormone Plasma Membrane Transport Defect
Adrenergic beta-Agonists
Polychemotherapy

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