PMID: 5251May 1, 1976

Effect of beta-adrenergic agonists aerosolized by freon propellant on tracheal mucous velocity and cardiac output

M A SacknerA Wanner


The present study was designed to assess the effects of two beta-adrenergic agonists, isoproterenol sulfate and carbuterol hydrochloride, and aerosolized Freon propellant (a mixture of Freon II, Freon 12, and Freon 114) on tracheal mucous velocity and cardiac output in anesthetized dogs. Five groups of ten animals each received the following dosages of aerosols: Freon, 20 puffs; isoproterenol, four puffs; carbuterol, four puffs; isoproterenol, 20 puffs; and carbuterol, 20 puffs. The puff was delivered by a standard metered aerosol; each puff of isoproterenol spray contained 75 mug of isoproterenol sulfate, and each puff of carbuterol spray contained 100 mug of carbuterol hydrochloride. Tracheal mucous velocity was not changed by receiving Freon, but administration of both isoproterenol and carbuterol caused a significant increase in this measurement, with peak increases ranging from 74 to 111 percent above control values. The duration of action for four and 20 puffs of isoproterenol and for four puffs of carbuterol was two hours. Twenty puffs of carbuterol increased tracheal mucous velocity for three hours. Administration of carbuterol effected a slightly larger increase in cardiac output than isoproterenol. The duration of act...Continue Reading


Mar 23, 1975·The New England Journal of Medicine·E R McFadden
Jan 1, 1974·Respiration; International Review of Thoracic Diseases·J Iravani, G N Melville
Jan 1, 1974·Respiration; International Review of Thoracic Diseases·A van As
Mar 1, 1965·The American Journal of the Medical Sciences·A A COHEN, F C Hale


Oct 24, 1995·European Journal of Pharmacology·S LindbergT Runer
Jan 1, 1993·Life Sciences·M JohnsonC J Whelan
Feb 1, 1989·The American Review of Respiratory Disease·M J Sanderson, E R Dirksen
Jun 20, 2002·Clinical Otolaryngology and Allied Sciences·W NaroznyE Pegiel-Sićko
Jan 1, 1984·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·V T Popa
Sep 1, 1979·The American Journal of Medicine·A Wanner
Jan 1, 1982·Progress in Clinical and Biological Research·P Verdugo
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May 17, 2002·Journal of Applied Physiology·Jeffrey I FrohockMatthias Salathe
Jan 1, 1978·Postgraduate Medicine·P B Francis

Related Concepts

Adrenergic beta-Agonists
Aerosol Propellants
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Hydrocarbons, Halogenated
Mucous Body Substance
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