PMID: 590180Jan 1, 1977

Effect of beta-adrenergic blockade on acid-base balance in experimental hypertension

Eksperimentalna meditsina i morfologiia
K IanevA Delibasheva

Abstract

On rats with experimental hypertension by method of Selye, modified by Kolarova, distributed in two groups--treated by obsidan and untreated, the following parameters on the 1st and the 3rd month after the operation were studied: pH, BB, SB, AB, BE, PaCO2, TCO2, PaO2, and SaO2. In the hypertonic animals we establish a decompensated metabolic acidosis on the 1st month and a metabolic acidosis with a marked respiratory compensation on the 3rd month. The hypertonic animals, treated by obsidan, demonstrate a sharp tendency to normalise the parameters of the acid-base status on the 1st month and normal values on the 3rd. The protective obsidan effect observed on the hypertonic rat we discuss as a result of metabolic and functional influences of the beta-adrenergic blockers.

Related Concepts

Metabolic Acidosis
Hypertensive Disease
Kidney
Lung
Rexigen

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