PMID: 40786Jan 1, 1979

Effect of beta-adrenergic drugs on humoral immune response factors

Eksperimentalna meditsina i morfologiia
R OvcharovG Gencheva

Abstract

The authors examined the influence of beta-adrenergic stimulators Isoprenaline and Salbutamol as well as beta-adrenergic blockers Propranolol, Practolol and Pindolol on the proliferation of cells, forming plaques, 7S-immunoglobulins, hemagglutination titres and hemolytic activity of the complement. Primary stimulation with subsequent inhibition was induced by beta-adrenergic agonists and inhibition--by beta blocker Propronanol in a base of 10 mg/kg on the proliferation of cells, forming antibodies. The results were in correlation with hemagglutination titres. Salbutamol and beta-blockers inhibited immune hemolysis. The mechanisms of the observed effect are discussed in respect to the specific and nonspecific effect of the drugs used.

Related Concepts

Adrenergic beta-Agonists
Adrenergic beta-Antagonists
Antibody Formation
Antibody-Secreting Cells
Complement Fixation Tests
Immunodiffusion Measurement
Cavia porcellus
Hemagglutination Test
Polyglobin
Variolation

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